Hello trt, I hope you find something that works. I used the promithezine at first and it didn't work so I went to the generic zofran, ordanestron. It has worked very well. I take it as soon as I get up in the am. I remember reading alot of post where people used combos because one would not sustain a full day without nausea. You may check out the archives to see if there is anything in there. Sorry I couldn't be more help. But I am rooting for you. I remember being very dicouraged for about a week trying to find something that would work. Hang in there. Lee