Hi Steve! Where are you getting treatment? I tried Amofostine & could only take 3 days before they actually cut me off because of bad allergic reaction. It would put me into sneezing fits & send my blood pressure real low & by the 3rd day by the time I got from the hemonc floor to the basement to the rad dept I was shivering & lethargic & sneezing! They wrapped me up in blankets & put a heat lamp over me & made me drink fruit juice until it wore off, about 30 minutes, & then I went on to my 3rd imrt dose. Pretty strange stuff. Everybody seems to have all different experiences with that stuff. My radonc guy said it was only expected to help protect about 10% more parotid function anyway if one could get through it. I definately have reduced spit production in the area around my tongue & back of throat, but it's only a problem early in the morning when I first wake up. It wouldn't be much of a problem except that the structure at the back of my mouth/throat has changed & now when I sleep air circulates in & out of my mouth from my throat & dries it out even more. It's kinda wierd, my mouth is not open, I breathe through my nose, but since so much of my tongue is sort of nonfunctional, it does not close off the back of my mouth. Bottom line is I don't think I missed much by not having the Amofostine & any changes are really not that big a deal considering the fact that I am an alive, living & fully functional, happy human being today! I had an absolutely delicious meal tonight! Boneless, skinless chicken breasts smothered & baked in bbq sauce, Bush's baked beans & tomato/onion/olive oil salad! Very delicious, easy to swallow & healthy! Desert was fresh strawberries with a little chocolate cake! The cake was a little tough to deal with, but a glass of milk took care of that. Keep yer chin up Steve! All the treatments will be over soon & you can get on with your life. Erik