I think he means "small dose". And Gail is speaking in absolutes, (which we have agreed not to do here) when she says that Amifostine does work. It does not have beneficial effects in everyone that uses it, and it is poorly tolerated in about 50% of the people who try to use it through their course of treatments. Since OCF is working with the company who manufacturers it on an awareness campaign, I have had a good look a the actual numbers from them. They acknowledge that there are two issues that preclude doctors from even mentioning it to patients (something they would like to over come by having patients ask their physicians about it to begin the dialog) and that is about a 50% effective rate, and a poor tolerance to the side effects. Having said all that, I think that the POTENTIAL benefits are worth trying it to see how well you can tolerate the side effects, since you MAY indeed benefit from it.