One final opinion, since the Benedryl has come up again. It is not the Benedryl that is the problem, it is the swollowing of the compound that makes you sleepy. And, I thought the Nystatin was a treatment for Thrush. I would avoid the amateur pharmacology and call the doctor to confirm why he presribed it. The mouthwash works well in the 1/3,1/3,1/3 mix and I would just stick with it, no need to re-invent the wheel here.