Toward the end of the 1st yr of my husband's tx, we had amassed more prescription drugs than I could keep up with. I started meeting with our pharmacist on a regular basis to talk about all the meds. John was on. On several occasions he alerted me that the combination was not so good and I would call the Docs to rethink the situation. Our family Doc got him in trouble on several occasions[trying to be helpful]. You really do need to be vigilant about the drugs. One of the drugs John absolutely could not tolerate was Fentanyl. Amy in the Ozarks