The combined weekly chemo/RT is quite common. One of the reasons people looked into this is the toxicity associated with the chemo, and how to lower it.
By chemo in this context, I mean just single agent treatment, usually cisplatin although sometimes carboplatin is used. Generally, from what I read, combination chemos (cisplatin/5FU/Taxodere are not used) during RT. Erbitux is also used together with RT.

In my case specifically, the cisplatin dose for the weekly application was 30mg/m2, this is a lot less than what you get if you do this every 3 weeks when the dosage is 90-100mg/m2. Therefore the weekly treatment makes you a lot less sick. You can also make the argument that the weekly dosage keeps more drug in your body to do its work. In my experience the weekly cisplatin was tolerated really well. You should however watch out of ringing. This may still happen, even at the lower concentration used in weekly treatments. Report this to your MO. It did in my case and I am now on weekly carboplatin. I have rads in the morning and each Thursday I get chemo (outpatient) following the radiation. There is no problem combining the treatment, and I drive myself to both "events". Until you know how you handle this you should have a backup plan, also this may change during the treatment.

The only thing I have noticed is that by Wednesdays I feel a bit queezy, which means that on Tuesday I take antinausea med (1 promethazine) which does the trick. Other what I get during the chemo and the above Promethazine I do not take anything. I too was given a 3 or more additional drugs to combat the nausea. I have not taken them except for the first time. When I discontinued them I informed the MO.
One more thing, the cisplatin infusion is done quite slowly and therefore takes a long time, bring something along to do. Should they switch you to carboplatin the infusion is a lot faster and you are out of there in less than half the time.


Best

M