Hi all - I'm new here, newly diagnosed, just had surgery, and would love your insight into my situation.

Short version:
I'm 36 years old, male, no risk factors other than very occasional cigar; was recently diagnosed with invasive squamous cell carcinoma of the left lateral tongue (June 2021). I had a partial glossectomy in July to remove the area of concern. Here's the odd part: The post-surgical biopsy did not find any residual carcinoma. This makes me wonder if the original Labcorp biopsy diagnosis of SCC was incorrect. Has anyone ever come across something like this?

Full details:
April 2020 - wisdom tooth extraction
May 2020 - noticed that newly exposed molar was irritating tongue; figured it was temporary.
July 2020 - started using “mouth sore” mouthwash to heal it - did not work. Continued to live with it as-is for several more months.
February 2021 - increasingly bothering me, mouthwash and salt water not helping
May 2021 - accident at home resulting in severe bite to this area of tongue (seemed to “bite off” the previous bump that was there)
Late May 2021 - starts becoming painful to eat and talk
June 2021 - finally went to dentist to have molar filed down, and to check out the tongue sore. Dentist refers me to oral surgeon for biopsy.
Biopsy performed (Labcorp) June 29, 2021. Biopsy tissue sample size was 0.6 x 0.6 x 0.3 cm. Biopsy Results one week later: INVASIVE, MODERATELY DIFFERENTIATED SQUAMOUS CELL CARCINOMA. THE DEEP AND LATERAL MARGINS ARE INVOLVED.
At this point, oral surgeon refers me to Head and Neck specialist. Head and Neck surgeon accepts the Labcorp biopsy at face value (no slide review or re-biopsy). CT scan shows no lymph node involvement. Tumor appears small. Surgeon schedules me for partial glossectomy without neck dissection.
July 19, 2021: Partial glossectomy surgery. The surgical biopsy from the glossectomy finds no residual carcinoma. Full pathology report:
NO RESIDUAL IN-SITU OR INVASIVE CARCINOMA IDENTIFIED.
FOCAL MILD TO MODERATE DYSPLASIA WITH PARAKERATOSIS.
BIOPSY SITE CHANGES WITH MULTINUCLEATED GIANT CELLS AND CHRONIC INFLAMMATION.
SPECIMEN MARGINS NEGATIVE FOR HIGH GRADE DYSPLASIA.


My questions:
If my initial biopsy (Labcorp) found invasive SCC that went all the way to the margins of the sample, how is it that no carcinoma was found during the partial glossectomy? Wouldn’t there have been some SCC remaining that the first biopsy left behind?
Is it possible that the Labcorp pathology report was wrong about invasive SCC? Is it possible that irritated or damaged tissue was misread for SCC? Does that happen?

Last edited by MMarvel; 07-29-2021 05:17 PM.