Hi,

according to the literature. In cancer, the term "differentiation" refers to how mature the cancer cells are in the tumour which also refers to the way they developed. Differentiated cells resemble to normal cells but then they grow and spread at another rate then undifferentiated or poorly diffrentiated tunour cells. The poorly differentiated cells lack structure and function and subsequently grow uncontrollably. There are 3 ways of indicating it, well differentiated, moderatly differentiated and poorly differentiated. Consequently, the first being the optimal one.

Having said all this with cancer and its prognosis especially with this kind of cancer they are many other factors to consider. Differentiation is only one of many!!!

Hope this helps and think positive,

Marie-Lyne