I may have heard something as to the effect Erbitux isnt as effective when used a second time, but Im not certain of all the details. I know Ive heard that many doctors still say radiation can only be done once but Ive seen it done 2 or even 3 times. This is done only on a individual case by case basis with many variables. If Erbitux can only be used once Im sure it would be similar to the radiation statement where in certain instances it could be the best option. Next time you see the medical oncologist, ask them what they know of this and please let us know.