The MO's staff might have the best insight as they have a lot more direct and frequent contact with the patients. See if you can informally ask a few what they see.

If they are giving the same drug but only different schedule and dosing, then one can likely assume the weekly dose will be greater than the fractions given on a daily basis.

My personal experience is the longer between dosing means harsher side effects as the body gets more chemo on the less frequent cycle. I did really well on weekly carbo and had a much harder time on the every three cycle. But that was a more harsh blend too which I am certain did not make it easier.

Good luck
Don