If you want to seek out one of the top CCCs I know that md anderson in Texas is amazing. What Christine said was true. Incurable is terminal. Sadly mets to to the lungs is almost always fatal. There are a few people here undergoing treatment for lung cancers r/t oral cancer - check the recurrence section for their stories. I would ask about clinical trials and push for a second opinion. Miracles do happen - and I would be hoping for one for your sister. She's so young. Sometimes your do everything right from a treatment standpoint but the cancer is so aggressively hard to catch. Her tumor was very large. The biopsy of her lungs is to determine if it is mets or if it's a different cancer. There is actually a higher rate of survival if it's actual lung cancer and not oral SCC that's moved. Hey are also doing some kind of a response therapy in California (biopsy samples can be sent there to see what chemo her cancer responds best to. I would ask about this. Sometimes all you need to do is buy some time and maybe a better treatment will come along. Hugs to you and your family.