Thanks, Paul. I have no history of heart problems or diabetes. The appendages themselves are not numb, its very surface level like the skin is numb. I was curious about nerves because I had a similar issue on my head in a neck compression accident when I was much younger, but the numbness went away in a number of hours in that situation.

I know a biopsy is the only way to diagnose, but the doctors have refused to perform one, even though they acknowledge it is enlarged. Since blood work is all I have to work off of, I was just curious if metastasis would elevate inflammation markers, white blood cells, or lymphocytes.