I am not sure if HPV- is more aggressive, I just know that studies have shown HPV+ responds much better to treatments than HPV-. What I just read was that the HPV hijacks the host cancer cell leading to expression of a viral antigen on the surface, causing the patient's immune system to ramp up and fight the cancer.

Josh, 24, don't smoke/drink

5/29/13 Biopsy
6/3/13 DX stage 3 HPV- SCC at BOT
6/14/13 Hemiglossectomy, neck dissection, second surgery to add stitches
6/21/13 PEG
6/23/13 Incision opened to drain infection
6/26/13 Discharged from hospital
7/22/13 IMRT starts