I ended up in the ER with 3 enemas when it got so bad one time that I started vomiting and couldn't stop. After that, I used a lot of stool softeners, Fiber-con, prune juice, suppositories, and Fleets. The only pain I had that was worse was when I had mucositis, and I got drugs for it! I always thought it was ironic that I had no pain from something that was killing me and such intense pain from something as simple as constipation.