Hi Ed,

I have access to most articles (abstracts at least) and can find nothing that tests whether smaller doses causes no further damage. I was under the impression that ANY further doses would cause further damage but maybe not as much???

What jumps out for me is that your doctor is dismissing carboplatin which is proven in this setting, but is prepared to "underdose" you with cisplatin. Does he know this dose works? And if so, is he confident the effect would be better than carboplatin? This is the question that I would be asking.

Have you already had two doses of cisplatin? There are a few studies where patients could not complete their planned 3 doses and their outcomes were quite similar to those that did all 3.