Hoping someone can help with this...hubby now has TSH of 3.89, years before dx was .67. Symptomatic for hypothyroid...was cold all the time - wrapped up in winter clothes during a heat advisory last year, mood swings, extreme fatigue, etc. Convinced doc that they should be looking at symptoms etc and not lab saying 3.89 is normal (3.0 will happen here in the next century). Started synthroid at 50 mcg and he had hot flashes like crazy after 2 weeks of tx (kids and I were wrapped in sweaters and blankets and I never want to hear about MY menopause again) First the doc said cut to 25 mcg and dh refused due to the side effect...now doc says 100 mcg. Any of you guys have hot flashes with synthroid? And did you need to be adjusted up or down? I've exhausted myself searching for an answer. All I'm finding is that this is one of the side effects that says call your doc. Thanks.