Actually I was worried about the same thing the study I read said no (go figure!!!) I cant remember the details but it had something of sugar (as its not really a sugar) but I used it from week 3- 8 (two weeks post rads) and then stopped now I only us it if I have an oral irritation, (not often!!!) I think maybe long term use - might possibly cause issues but I also rinsed frequently and brushed x 2 and used a water pik to Clean around my gums (still do) so far so good... My dentist says he's happy !