My Dad is at the end of the infamous week 3 and like others, fatigue socked him good as rads are cumulative. He's the Evil Kenieval of life mishaps and has one of the highest tolerances to pain I've seen, and it's hard to keep him on meds but our experience urges me to suggest that you research your meds and be prophylactic with them. His CCC is very vigilant about this and encourgages swallowing as much as possible, and as an observer I can share the fatigue limits physical work, but exercise is critical.