Hi, I had the same question about the biopsy myself. My first was negative, the oral surgeon who my dentist had sent me to twisted my arm to get a second. He really cut a lot out.I can still remember how upset I was that day! Well the Cancer exploded up into my mouth , It grew by the day, Honest to God it was like a science fiction movie. I do not want to scare anyone, this is just something that happened to me. When I got to the ENT , I said this did not look like this 8 or 9 days ago! They rushed me thru a Tumor Board and into surgery so fast I was dizzy. Later I asked him Why? He said he did not know. I said everyone says it was because the tumor was cut into , he said that was what people said in the old days because they could not test and see what was in a person like now and they would get them on the table open them up and have to close right away, they were in bad shape and people would say it was because they cut into it.So I really do not think anything they did made it grow faster. This is a fast growing type all by itself.I do not know about chemo, someone else will have to give that a try , I do know most people try anything they can throw at them to get rid of it. Best of Luck!