[quote]One study said 50% didn't complete all the cycles or were unable to do CRT to follow due to the toxicities. On a postitve note, it works, very well, especially with HPV positive OPSCC. [/quote]I can attest to the brutality and effectiveness of TPF IC. I was nearly dead by the end of the 3rd round and TOLD them I needed more time to recover before starting CRT. By the same token the PET reported "near to complete resolution". I'd do the same treatment in a blink.

HPV 16? I tried to follow along but more confused than before. I just thought a positive p16 staining meant your odds of long term cure just leaped about 30 points.

I always thought HPV "negative" was associated with the smoker/drinker oral cancer with poorer outcomes.

Glad you are here to keep us, well at least me, from getting too far off the science trail.

Thanks Don