Great article. My random thoughts:
Both individuals' and organizations' will to survive is on the most efficient and easiest way to get from point A to point B.

Prevention takes a back seat when you are vividly seeing and feeling the short term consequences of each decision to get through the day.
Research groups survive on funding.
Politicians survive by re-election.
Medicare survival needs funding and/or cuts. How to manage the ratio of available tax payers vs recipients.

Most intriguing to me is the Biomarker research. That is where I would put my money. This seems to have the most promise on better quality of life for society as a whole.