I had TPF induction chemo ..Taxotere, Cisplstin and 5-FU in 2009, which hospitalized me for 6 months, paralyzed from the waist down for 10 months, lost 100 lbs, blinded in one eye, and almost died. I stil have severe side effects three years later..severe neuropathy..lucky to walk one block, need epogen shots and tranfusions, and many more with hundreds of dr visits. It's very effective, controversial, and has good response rates with HPV, but I would not have done it, being what I experienced, and know now that it's very toxic, and can delay your treatments for the real curative, and that is radiaton. It delayed my completing treatments by a year, and most drs believe it's a cause of my recurrences. Everyone is different, and responds differently, but this wasn't for me. I went from from working full time, being physically active at 48, and after only 5 days induction chemo was disabled.