From the scant info I have read, it doesn't seem to me that MD fits the HPV+ profile very well:

Isn't he a bit old (66)?

Doesn't Stage IV HPV+ OC normally present as one or more obvious large swollen lymph nodes and a small primary?

He said on a recent "Access Hollywood" interview that he saw doctors last January and May about a persistent sore throat, then went in August when his tongue was bothering him.

http://www.accesshollywood.com/mich...flirty-texts-to-matt-damon_article_42013

Don
TXN2bM0 Stage IVa SCC-Occult Primary
FNA 6/6/08-SCC in node<2cm
PET/CT 6/19/08-SCC in 2nd node<1cm
HiRes CT 6/21/08
Exploratory,Tonsillectomy(benign),Right SND 6/23/08
PEG 7/3/08-11/6/08
35 TomoTherapy 7/16/08-9/04/08 No Chemo
Clear PET/CT 11/15/08, 5/15/09, 5/28/10, 7/8/11