My mother had a CT Scan done and on Monday we will see the doctor for results. If the scan doesn't show any good results then the doctor said he will stop the Cisplatin. He said the next option would be Erbitux.
A while back someone posted Erbitux saved their life. Im wondering about the side effects. My mother has been through a lot and has lost so much weight already. I'm sure its no walk in the park but just wondering if its worse than Cisplatin.
Thanks
Heidi
The chemo you are talking about is called Erbitux. Its also known as cetuximab. One of the side effects is a rash. from what I understand the bigger the rash, the better the Erbitux is working.
Thanks Christine
It's called Erbitux thanks for the correction. As you can see I'm still learning. I'm sure a rash wont feel to good but it's probably better to deal with than what she has been through. I don't think my mom can handle a 3rd round of the Cisplatin. the 2nd one really took a toll on her.
Happy Holidays
Heidi
I had Erbitux concurrent with my IMRT treatments. No major side effects except for the rash. IV Benadrill was my friend for that.
Good Luck Heidi!
I had Erbitux also and am in my 2nd month of recovery (from the side effects) from both the Chemo and the radiation. One of the side effects has been "Chemo Brain", a condition similar to CRS (can't remember stuff). My wife noticed my fogginess about the 3rd week of my 7 week treatments and I still have it; along with some others. My dr.'s are telling me that it may take 4-6 months to get back to where I was before. I am hopeful, but I am not completely sold that I will ever be the same as I was before; not in that time frame.
yes I'm going thru treatment with Erbitux now. I had 1 treatment have rash on side of my face but not real bad. Doing Erbitux before surgery they say it helps for after. After 1 treatment I noticed 90% of pain is gone and the tumor seems to went down some,I have 2 more treatments left then surgery. I go the next 3 Mondays I'll try to let you know how things turned out
There are two rare, but severe, side effects with Erbitux and that is an allergic reaction, and heart attack, which mostly occur the first or 2nd infusion in a small percentage of people. Benadryl is given to help with the allergic reaction, and staff monitor you closely, and you are to report anything out of the ordinary. The other which is expected, and sign of the Erbitux working is the rash, which is managed by antibiotics. They say for about 5% of head and neck cancer patients this drug doesn't work due to the Kras gene mutation, but there is no assay test to find this out unlike for colorectal cancer, which blood test is given before starting to see if one is a candidate or not.
http://www.erbitux.com/index.aspx
My husband has had 5 Erbitux infusions and 12 IMRT Radiation treatments. The worst of the rash/acne was after the first 2-3 infusions and has calmed down now. The Dr gave him a gel to help dry the acne and that helped a lot. He now has dry skin that we use a moisturizer for. His appetite has gone down and we are using the Gtube for supplemental feelings.
after my 2nd treatment of Erbitux and chemo,I had I guess what you can say a very sour belly.Didnt have fever this time,but it pretty much put me on the couch the next day. I do have a rash dry lips but hardly any pain,looks like things are shrinking. Seems like the day of and after treatment I have a hard time eating,but have been able to eat that night and feel lots better
I am currently being treated with Cetuximab/Erbitux after on and off complicated treatment regimen (due to bone necrosis in jaw, likely caused by bevacizumab/Avastin--another targeted therapy drug)to treat stage IV mets to lungs, which was primary'd from throat cancer back in 2012. My most recent treatment soup has been carboplatin(orig cisplatin--carbo is less harsh), taxotere, and the erbitux, which was added early last November. I took a break from all treatment after finishing the latest four treatment, 21-day cycle, carbo/tax regimen.
Most recent CT-Scans have shown very positive results to mets in lungs. This came at a price, the side-effects were hard on me.
From everything I've read though, and I read everything I can get access to, the side-effects are worth putting up with. Of course, that is barring allergic reaction, unbearable side-effects, etc,. Some people continue with Cetuximab/Erbitux for years as "maintenance therapy".
I had minor rash on chest. My face and hands were affected the worst. At the end of about 4 or 5-weeks on Cetuximab my face appeared sunburnt, with skin flaking. Along the way I treated this with Uecerin cream. Hands dried so bad that I was wrapping bandaids around half my finger tips from tiny deep cuts that opened on their own, as well as various nicks and scrapes. I used Uecerin on hands also. I had really weird eye-tearing thing going on too. Phys Asst told me it wasn't pink eye, but it looked like it.
My magnesium levels dropped very low throughout this experience and still are not right yet; they call this hypomagnesemia. I am taking over the counter supplement currently. There were few times the IV'd magnesium into me during chemo. I have had muscle and arthritic-like joint pain from this. No energy, malaise kind of lethargy too. Things can get dangerous if magnesium levels (as well as others) aren't kept in correct range.
Yeah, that's my latest course of self-study, fluids and electrolytes. Ahhh, but I've said enough here, I'm not trying to hijack the thread. I thought I a little bit more first hand detail in answer to your question wouldn't hurt here.
On Jan 20th I start "maintenance" regimen of Cetuximab/Erbitux alone, which will be cut back to every other week at my request. If anyone wants Erbitux updates, check back with me. We'll know after a while whether or not it was the targeted therapy drug that shrunk, and in some cases flat out disappeared, my tumors.
Malwicker
I wish you the very best in your treatment. Someone posted on the board a while back that Erbitux saved there life. Hopefully you will get some good results from your treatment. I know its no walk in the park but Hang in there through the side effects. Time will pass and you will be recovering soon.
Good Luck
Heidi
Malwicker - so happy this is working for you. The side effects suck but it sounds like you are slowly gaining ground so this is great. Hugs.
Thanks everyone. I start seven rounds of Erbitux next week and was basically given the breakdown shared here. I had Cisplatin 8 years ago and I was told that although it won't be a walk in the park this will be much easier on my system! Ready to roll and get back to another new "Normal."
My thanks as well to everyone who posted on this topic. I just started on cetuximab last week so reading what you guys have to say has been helpful.
Before starting on cetuximab I did some research with my friend Google and found some interesting info. If you also decide to look into it, you'll come across frequent mention of two clinical trials, the Bonner trial and the EXTREME trial. In both trials, cetuximab prolonged survival and had other quality of life benefits.
The Bonner trial was for patients with locoregional advanced HNSCC and measured effectiveness of cetuximab when given with radiation. There's plenty of articles on it, you can find them by googling "cetuximab" and "Bonner" or read this one:
http://www.cancer.gov/clinicaltrials/results/summary/2010/head-neck-cetuximab0604The EXTREME trial differed from the Bonner trial in two respects. Instead of patients with locoregional advanced HNSCC, it was performed with patients having recurrent and/or metastatic HNSCC, and instead of measuring efficacy in conjunction with radiation, it measured efficacy when used in conjunction with platinum-based chemo. You can find plenty more info by googling "cetuximab" and "extreme"; here's a recap of it on cancer.gov:
http://www.cancer.gov/clinicaltrials/results/summary/2007/cetuximab-head-neck0607Hopefully this won't apply to anyone here, but cetuximab is/was primarily used for colorectal cancer. Happily, it was found to also work on HNSCC. When researching cetuximab, you'll come across plenty of articles on colorectal cancer, so you can hopefully disregard that info.
Andrew, In reading your post one thing resonated with me. I was told that this drug would benefit my quality of life from a side effect standpoint. If it's doing the job then who would want to disagree with that type of thinking! The majority of us go through plenty during our journey anyway!
Thank you for sharing your research.
Andrew, these are old Trials/studies.
The Bonner trial does state that the outcome for patients treated with radiation and Erbitux was better than for those just treated with radiation. It also states that the outcome for patients treated with radiation and Erbitux was still not as good as for those treated with the standard radiation and Cisplatin/Carboplatin.
I don't want to rain on your good news about Erbitux. I'm sure someone with more knowledge than me will come along shortly and post links to more up to date trials.
Hope all goes well for your treatments .
Tammy
Tammy, I merely noted Bonner and EXTREME since they are landmark trials and I wanted to provide background info for anyone who may not have been familiar with them. (I imagine a lot of people here are already aware of them but they had not yet been mentioned in this thread.)
Unfortunately, it is true that cetuximab w/radiation is not as effective as standard CRT (it was not the intent of the Bonner trial to compare them.)
I may be completely wrong about this, but it is my impression that cetuximab is regarded as the best alternative for those patients in whom a more intense treatment of platinum-based chemo is not the best option. It also seems, as I understand it, to be regarded as the best option for those who have already undergone one of the standard platinum chemo txs.
Please correct me, someone/anyone, if I am wrong about that. I will have to search this site for previous discussions of cetuximab to further educate myself. You guys who have been there, done that are a wonderful source of knowledge, as well as inspiration and hope. Thanks for all you do.
And Tammy, thanks for the best wishes. I'm also wishing the continued best for you and your husband and family.
Here is a 2012 article from MSKCC to the editors of The Journal of Clinical Oncology about Erbitux replacing Cisplatin, outside clinical trials, that may be of interest for further reading. The RTOG 1016 trial testing the efficacy of Erbitux vs Cisplatin is still on going, I believe, and not completed yet. There were quite a few discussions on this blog regarding Erbitux a few years ago.
http://jco.ascopubs.org/content/early/2012/11/30/JCO.2012.46.9049
Thanks Paul. I had you in mind as being the more knowledgable person re the trials and Erbitux.
Hope all is well with you,
Tammy