#70410 02-23-2008 06:36 AM | Joined: May 2006 Posts: 720 Likes: 1 "Above & Beyond" Member (500+ posts) | OP "Above & Beyond" Member (500+ posts) Joined: May 2006 Posts: 720 Likes: 1 | An article in Sunday's New York Times discusses the issues involved in marketing Gardasil for boys, and notes the vaccine could receive FDA approval for boys in 2009. The role of HPV in some head and neck cancers is very briefly noted in the last third of the article. -- Leslie
Leslie
April 2006: Husband dx by dentist with leukoplakia on tongue. Oral surgeon's biopsy 4/28/06: Moderate dysplasia; pathology report warned of possible "skip effect." ENT's excisional biopsy (got it all) 5/31/06: SCC in situ/small bit superficially invasive. Early detection saves lives.
| | | | Joined: Jun 2007 Posts: 214 Gold Member (200+ posts) | Gold Member (200+ posts) Joined: Jun 2007 Posts: 214 | I was wondering when they were going to market this for boys. It only makes sense!
Left tonsil SCC, HPV+. T2N0M0. Tonsillectomy 3-07, bilateral radiation, cisplatin 3x, Tx completed 6-06. Clear PET 4-01-2008. Thyroidectomy 5-9-08, resulting in permanent surgically-induced hypoparathyroidism and adrenal problems. Bummer. | | | | Joined: Sep 2006 Posts: 8,311 Senior Patient Advocate Patient Advocate (old timer, 2000 posts) | Senior Patient Advocate Patient Advocate (old timer, 2000 posts) Joined: Sep 2006 Posts: 8,311 | girlcat,
They have been going thru the FDA approval process for quite some time. Let's hope it receives their approval quickly.
David
Age 58 at Dx, HPV16+ SCC, Stage IV BOT+2 nodes, non smoker, casual drinker, exercise nut, Cisplatin x 3 & concurrent IMRT x 35,(70 Gy), no surgery, no Peg, Tx at Moffitt over Aug 06. Jun 07, back to riding my bike 100 miles a wk. Now doing 12 Spin classes and 60 outdoor miles per wk. Nov 13 completed Hilly Century ride for Cancer, 104 miles, 1st Place in my age group. Apr 2014 & 15, Spun for 9 straight hrs to raise $$ for YMCA's Livestrong Program. Certified Spin Instructor Jun 2014.
| | | | Joined: Mar 2002 Posts: 4,912 Likes: 52 OCF Founder Patient Advocate (old timer, 2000 posts) | OCF Founder Patient Advocate (old timer, 2000 posts) Joined: Mar 2002 Posts: 4,912 Likes: 52 |
Brian, stage 4 oral cancer survivor. OCF Founder and Director. The first responsibility of a leader is to define reality. The last is to say thank you. In between, the leader is a servant. | | | | Joined: Mar 2008 Posts: 67 Supporting Member (50+ posts) | Supporting Member (50+ posts) Joined: Mar 2008 Posts: 67 | Brian, Are you aware of any trials where the Gardasil vaccine is being to men who developed oral cancer and were p16+? My doctor at UCSF said there is no clinical data to suggest a benefit but she would still get the vaccine after I heal from my treatments. She said it is possible that it might do something to boost my immunity against the disease. I would love to hear your thoughts on this matter.
Also, is there any benefit to determining the exact cause of a p16+ test?
Thanks
Frank
SCC Right Tonsil Dx 2/25/2008 at age 43 T1N2B M0,Stage IVa 8mm primary removed 3/5/08 4cm lymph node removed 2/22/08 2 additional sub cm nodes Tx at Stanford: 30 x IMRT, 2 x Cisplatin, Started radiation 3/27/08, Completed 5/7/08 p16+, HPV 16+ 2 Year Post-TX PET CT 5/10 - CLEAR
| | | | Joined: May 2006 Posts: 720 Likes: 1 "Above & Beyond" Member (500+ posts) | OP "Above & Beyond" Member (500+ posts) Joined: May 2006 Posts: 720 Likes: 1 | Johns Hopkins has been conducting a Phase I clinical trial of a vaccine (not Gardasil) for patients with HPV+ tumors, though it sounds from the most recent postings (last year) that the trial has closed. These three threads have a lot of information about it. -- Leslie
Last edited by Leslie B; 03-21-2008 03:51 AM.
Leslie
April 2006: Husband dx by dentist with leukoplakia on tongue. Oral surgeon's biopsy 4/28/06: Moderate dysplasia; pathology report warned of possible "skip effect." ENT's excisional biopsy (got it all) 5/31/06: SCC in situ/small bit superficially invasive. Early detection saves lives.
| | | | Joined: Mar 2002 Posts: 4,912 Likes: 52 OCF Founder Patient Advocate (old timer, 2000 posts) | OCF Founder Patient Advocate (old timer, 2000 posts) Joined: Mar 2002 Posts: 4,912 Likes: 52 | I answered this question on another thread. What you should be interested in (as I am) are any positive results that come from this very small, and VERY early, trial of a vaccine against recurrence of the virus that Leslie mentions. The trial is closed. Now we wait to find out the results. You have to remember that understanding of it all, and the final commercialization of any vaccine that might result from it, is YEARS down the road, and millions of dollars in investments.
Brian, stage 4 oral cancer survivor. OCF Founder and Director. The first responsibility of a leader is to define reality. The last is to say thank you. In between, the leader is a servant. | | | | Joined: Mar 2008 Posts: 67 Supporting Member (50+ posts) | Supporting Member (50+ posts) Joined: Mar 2008 Posts: 67 | I want to know if the cause of my positive p16 test means that I am HPV positive. What is the best way to determine if I am, in fact, HPV positive, and if so, what strain? I have asked my doctors and they said the subject is of academic interest but of no clinical value. While I agree that the knowledge would not have changed my treatment decision, I want to know. There might be clinical value to the information in the future. Is it best to have the tissue tested while it is still fresh? How have others approached this issue? Any help would be appreciated. On another note, I had my first IMRT treatment today and will have my first concurrent Cisplatin treatment tomorrow. Thanks I
Frank
SCC Right Tonsil Dx 2/25/2008 at age 43 T1N2B M0,Stage IVa 8mm primary removed 3/5/08 4cm lymph node removed 2/22/08 2 additional sub cm nodes Tx at Stanford: 30 x IMRT, 2 x Cisplatin, Started radiation 3/27/08, Completed 5/7/08 p16+, HPV 16+ 2 Year Post-TX PET CT 5/10 - CLEAR
| | | | Joined: Mar 2002 Posts: 4,912 Likes: 52 OCF Founder Patient Advocate (old timer, 2000 posts) | OCF Founder Patient Advocate (old timer, 2000 posts) Joined: Mar 2002 Posts: 4,912 Likes: 52 | It means that a some point in the past you were for sure. Whether you are now is an unknown. There is no reliable means to test men at this point. Where would we collect the sample from? We don't know if it goes dormant, and if so where. You could do a blood test to look for a type specific antibody. But that is still a refection of the past. The odds are, from all previous studies, that you were type 16 positive. And as stated before this would be of unknown value to know, and other than 16 I do not know of any clinical work being done on the few other oncogenic versions in head and neck, because they are not major players.
Brian, stage 4 oral cancer survivor. OCF Founder and Director. The first responsibility of a leader is to define reality. The last is to say thank you. In between, the leader is a servant. | | | | Joined: Sep 2006 Posts: 8,311 Senior Patient Advocate Patient Advocate (old timer, 2000 posts) | Senior Patient Advocate Patient Advocate (old timer, 2000 posts) Joined: Sep 2006 Posts: 8,311 | Frank, I'm not sure I understand your question or the "no clinical value" statement made by your doctors. I assume your bio tested positive for HPV 16 which means that your cancer was caused by the HPV strain 16 and that has recently proved of clinical value, i.e. the difference between HPV + and HPV - cancer. But if your question is am I still HPV + ? and their response is "no clinical value" then I would still scratch my head. Yes there presently is no HPV test for males other than a bio but if you were still positive I would think that would be of some clinical value to someone and I would hope as I did with me that our rad Tx would kill not only the cancer but the virus as well. Not an expert here but I still have a million unanswered questions about this virus that tried to kill me.
David
Age 58 at Dx, HPV16+ SCC, Stage IV BOT+2 nodes, non smoker, casual drinker, exercise nut, Cisplatin x 3 & concurrent IMRT x 35,(70 Gy), no surgery, no Peg, Tx at Moffitt over Aug 06. Jun 07, back to riding my bike 100 miles a wk. Now doing 12 Spin classes and 60 outdoor miles per wk. Nov 13 completed Hilly Century ride for Cancer, 104 miles, 1st Place in my age group. Apr 2014 & 15, Spun for 9 straight hrs to raise $$ for YMCA's Livestrong Program. Certified Spin Instructor Jun 2014.
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