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Joined: Jul 2012
Posts: 3,267
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PaulB Offline OP
Patient Advocate (old timer, 2000 posts)
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Patient Advocate (old timer, 2000 posts)

Joined: Jul 2012
Posts: 3,267
Likes: 1
The FDA recently announced labeling changes to warn of risk for possibly permanent nerve damage from antbacterial fluoroquinolone drugs taken by mouth or by injection shortly after taking.

This may be the cause or worsened the effects of the severe neuropthy I have, which I didn't have before treatment in 2009, and even noiced the last two weeks it worsened after taking antibiotics for some teeth issues from radiation, but mine is not on their list, Amoxicillin and Clavulanate Potassium, yet. I did take Cipro back in May after surgery, and extensivly in 2010 for C-Diff.

They include:

Avelox
Cipro
Cipro IV
Cipro XR
Factive
Levaquin
Noroxin

http://www.fda.gov/Drugs/DrugSafety/ucm365050.htm


10/09 T1N2bM0 Tonsil
11/09 Taxo Cisp 5-FU, 6 Months Hosp
01/11 35 IMRT 70Gy 7 Wks
06/11 30 HBO
08/11 RND PNI
06/12 SND PNI LVI
08/12 RND Pec Flap IORT 12 Gy
10/12 25 IMRT 50Gy 6 Wks Taxo Erbitux
10/13 SND
10/13 TBO/Angiograph
10/13 RND Carotid Remove IORT 10Gy PNI
12/13 25 Protons 50Gy 6 Wks Carbo
11/14 All Teeth Extract 30 HBO
03/15 Sequestromy Buccal Flap ORN
09/16 Mandibulectomy Fib Flap Sternotomy
04/17 Regraft hypergranulation Donor Site
06/17 Heart Attack Stent
02/19 Finally Cancer Free Took 10 yrs






Joined: Dec 2003
Posts: 2,606
Likes: 2
Patient Advocate (old timer, 2000 posts)
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Patient Advocate (old timer, 2000 posts)

Joined: Dec 2003
Posts: 2,606
Likes: 2
I think there should be black box warnings on this class of drugs for anyone going through chemo or radiation. Most neurological or neuromuscular issues will be exacerbated. Musculoskeletal issues as well.

I think any MRI's with contrast prior to 2007 or so are highly suspect for fibrosis and vascular constriction and resultant kidney, liver, lung or heart failure. It was believed all fibrosis began with the skin but in 2003 post mortems were performed and the link to organs was established. Vascular constriction with electrolyte imbalance, specifically potassium will cause temporary and potentially permanent peripheral neuropathies. GFR should always be checked prior to using GBCA's. I don't see it being done but I know someone has to be reviewing lab histories before the MRI. The results can be fibrosis of any connective tissue in the body and even broken bones due to weaker connective tissue.


SCC Stage IV, BOT, T2N2bM0
Cisplatin/5FU x 3, 40 days radiation
Diagnosis 07/21/03 tx completed 10/08/03
Post Radiation Lower Motor Neuron Syndrome 3/08.
Cervical Spinal Stenosis 01/11
Cervical Myelitis 09/12
Thoracic Paraplegia 10/12
Dysautonomia 11/12
Hospice care 09/12-01/13.
COPD 01/14
Intermittent CHF 6/15
Feeding tube NPO 03/16
VFI 12/2016
ORN 12/2017
Cardiac Event 06/2018
Bilateral VFI 01/2021
Thoracotomy Bilobectomy 01/2022
Bilateral VFI 05/2022
Total Laryngectomy 01/2023
Joined: Jul 2012
Posts: 3,267
Likes: 1
PaulB Offline OP
Patient Advocate (old timer, 2000 posts)
OP Offline
Patient Advocate (old timer, 2000 posts)

Joined: Jul 2012
Posts: 3,267
Likes: 1
Interesting, Ed. I check, and most my doctors know my creatine is high or GFR is low, and bring it to their attention, if not. As for the diagnostic center, labs were never checked, I think, having only had Two MRI's, and others were CT, which contrast I can't have and PET/CT. They do have you fill out a questionnaire.


10/09 T1N2bM0 Tonsil
11/09 Taxo Cisp 5-FU, 6 Months Hosp
01/11 35 IMRT 70Gy 7 Wks
06/11 30 HBO
08/11 RND PNI
06/12 SND PNI LVI
08/12 RND Pec Flap IORT 12 Gy
10/12 25 IMRT 50Gy 6 Wks Taxo Erbitux
10/13 SND
10/13 TBO/Angiograph
10/13 RND Carotid Remove IORT 10Gy PNI
12/13 25 Protons 50Gy 6 Wks Carbo
11/14 All Teeth Extract 30 HBO
03/15 Sequestromy Buccal Flap ORN
09/16 Mandibulectomy Fib Flap Sternotomy
04/17 Regraft hypergranulation Donor Site
06/17 Heart Attack Stent
02/19 Finally Cancer Free Took 10 yrs







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