Brian,
Any comments on M. Gillison's presentation at ASTRO on the Analysis of the effect of p16 and tobacco pack-years?

Am I understanding correctly the she is saying to deduct 1% from OS (or PFS?) for each year of tobacco smoking regardless of HPV status? Abstract seems confusing!

If so, wouldn't it matter how long ago one quit?

also is abstract saying HPV+ (p16) had greater rates for secondary primaries (13% vs 11%) and nearly same distant metastases (11.1% vs 13%)?
Thanks

Abstract (only):
http://www.asco.org/ASCOv2/Meetings..._view&confID=74&abstractID=42843


Don
TXN2bM0 Stage IVa SCC-Occult Primary
FNA 6/6/08-SCC in node<2cm
PET/CT 6/19/08-SCC in 2nd node<1cm
HiRes CT 6/21/08
Exploratory,Tonsillectomy(benign),Right SND 6/23/08
PEG 7/3/08-11/6/08
35 TomoTherapy 7/16/08-9/04/08 No Chemo
Clear PET/CT 11/15/08, 5/15/09, 5/28/10, 7/8/11