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#81511 10-03-2008 07:46 PM
Joined: Jun 2008
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thought this sounded cool ... wondered if anyone else had heard about this?

(NaturalNews) A blue curing light used to harden dental fillings also may stunt tumor growth, Medical College of Georgia researchers say. "The light sends wavelengths of blue-violet light to the composite, which triggers hardening," says Alpesh Patel, a rising MCG School of Dentistry junior. "The light waves produce free radicals that activate the catalyst and speed up polymerization of the composite resin. In oral cancer cells, though, those radicals cause damage that decreases cell growth and increases cell death."

Mr. Patel, who has been working with Dr. Jill Lewis, associate professor of oral biology, Dr. Regina Messer, associate professor of oral rehabilitation and oral biology, and Dr. John Wataha, adjunct professor of oral rehabilitation and oral biology, studied 10 tumor-bearing mice, five treated with the light and five untreated.

He exposed half the mice to the blue light for 90 seconds a day for 12 days. Then the tumors were extracted and each one was split into two sections. Half were used to create slides for tissue analysis, and half were frozen to prepare protein extracts.

Tissue analysis indicated an approximate 10 percent increase in cell suicide, or apoptosis, in the light-treated tumors. The frozen protein extracts revealed a nearly 80 percent decrease in cell growth in the light-treated tumors.

"The decrease in cell growth, combined with increased apoptosis, helps explain why the tumors didn't grow as much because you have cells that aren't dividing and you have cells that are committing suicide," Mr. Patel says.

Dr. Lewis predicts treating the tumors with blue light sooner will increase the rate of apoptosis, possibly preventing the tumor from ever becoming measurable and easing treatment.

"One desirable feature we've observed with the blue light is that non-cancerous cells appear unaffected at light doses that kill tumor cells," says Dr. Lewis. "We're thinking that some day, blue light therapy may serve as an adjunct to conventional cancer therapy. Patients may, therefore, receive lower doses of chemotherapy, which would decrease the adverse effects most cancer patients experience from standard chemotherapy regimens."

Mr. Patel presented his findings at the 2008 American Association for Dental Research Student Research Group DENTSPLY/Caulk competition, winning third place in the basic science category. He and rising junior MCG School of Dentistry student Beth Rainwater were two of only seven students nationwide to be selected for the competition.

Source:

Medical College of Georgia (2008, June 28). (http://www.mcg.edu/)


Rita - Age 44
wife, mother of 4 - ages 3,16,21,24 & grandma to 1
(R upper) Maxillectomy 8/8/08 - UW / Seattle, WA.

===============================

"Those who think by the inch and speak by the yard, should be kicked by the foot."


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I have read somewhere also about this blue-violet light helping other medical conditions as well I believe it was that it helped arthritis type conditions...

I really hope that it works and can help fight cancer anything that kills cancer can't be all that bad


Dianne..treatment at cc at Victoria Hospital, London, Ontario...insulin dependant, Surgery Sept 8/08 Tracheotomy,composite resection and bilateral neck dissection, left radial forearm free flap... T2N0 squamous cell carcinoma. No radiation A little over 2 yrs clear YAY
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careful guys.
Blue and ultraviolet light cannot penetrate deep into tissue. So at best this MAY by applicable for surface treatment. You certainly would never be able to reach a lymph node or penetrate more than a few mm into tissue (if that).
When they use a UV light to initiate polymerisation then this needs just a few radicals to start the chain reaction. In order to achieve anything medically relevant you need a much much stronger light to create a LOT more radicals (if that is the mechanism). Also, damaged DNA by radicals or other means got us to this board in the first place!!!

BTW here is the article

http://www.bio-medicine.org/biology...oth-fillings-stunts-tumor-growth-3747-1/

Note!! it does NOT say what type of tumor was treated nor how nor what wavelength or intensity of light was used.
To be open minded I am following this up but I am highly skeptical. If I hear anything credible I will post this.

M






Partial glossectomy (25%) anterior tongue. 4/6/07/. IMRT start @5/24/07 (3x) Erbitux start/end@ 5/24/07. IMRT wider field (30x) start 6/5/07. Weekly cisplatin (2x30mg/m2), then weekly carbo- (5x180mg/m2). End of Tx 19 July 07.
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A bit more info:

There is one newer paper (dental materials 24, 2008, 1036-1042) where they warn against extended use of blue light exposure. In their study they induced cell death in human gingival fibroblasts. The cells irradiated were in 96 well culture plates.
So these are "normal" cells. (Inasmuch as a cell in culture is normal)

(J. Dent. Research. 83, 2004, 105-) where they looked at normal and cancer cell CULTURE. Ref therein states (Mechanism presumably mitochondria mediated)

also in 2005 http://www3.interscience.wiley.com/journal/112426016/abstract?CRETRY=1&SRETRY=0

and more recent: DENTSPLY/Caulk - Basic Science Category April 2008
These are poster sessions and not peer rewieved journal articles

http://iadr.confex.com/iadr/2008Dallas/techprogram/session_18878.htm

The first on is the mouse work (10 mice only). Cultured A431 human epidermoid carcinoma cells were injected subcutaneously into the abdomens of female mice and then treated with blue light.

In the second one (0630) Normal human epidermal keratinocytes (NHEK) and oral squamous carcinoma cells (OSC2) were seeded onto coverslips in six well plates, and treated with blue light.

This is certainly interesting but needs a LOT more research, and even then the physical properties of light may make this a surface treatment at best in my opinion.

M













Partial glossectomy (25%) anterior tongue. 4/6/07/. IMRT start @5/24/07 (3x) Erbitux start/end@ 5/24/07. IMRT wider field (30x) start 6/5/07. Weekly cisplatin (2x30mg/m2), then weekly carbo- (5x180mg/m2). End of Tx 19 July 07.
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Your comment about surface treatment at best to me means that they are going in a right direction. I just really hope for a cure period weather blue light green light purple light standing on your head for hours...I would just like to see a cure...so if it is at all promising keep researching till they get it right...or find something!!!! I know it isn't that simple but the bottom line is basically CURE!!!


Dianne..treatment at cc at Victoria Hospital, London, Ontario...insulin dependant, Surgery Sept 8/08 Tracheotomy,composite resection and bilateral neck dissection, left radial forearm free flap... T2N0 squamous cell carcinoma. No radiation A little over 2 yrs clear YAY
Joined: May 2007
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The point I was trying to make is that although this is interesting it is hardly a cure and even if you research it to death it may never be because of limitations.
I am just trying to inject some caution here. It is quite easy to kill/inhibit cancer cells in cell culture. It is another thing to kill them when they are in situ.


M





Partial glossectomy (25%) anterior tongue. 4/6/07/. IMRT start @5/24/07 (3x) Erbitux start/end@ 5/24/07. IMRT wider field (30x) start 6/5/07. Weekly cisplatin (2x30mg/m2), then weekly carbo- (5x180mg/m2). End of Tx 19 July 07.

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