Hi, Margaret, I can weigh in on the Erbitux. Jon's initial infusion was really scary also. Wild bloodpressures- heart rate going crazy- etc. However, after slowing down the infusion rate - what was supposed to take a couple of hours ended up taking all day with his Doc in attendance- he got through it and was able to take it thereafter. He did have most of the side effects described on the drug info sheet. He also opted for Carboplatin rather than Cisplatin because he had hand tremors and some hearing loss before tx. started. There are alot of hard decisions to make Amy in the Ozarks