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#96066 05-25-2009 08:54 AM
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My hopes were dashed last night on 60 minutes. I had been reading about red wine and cancer:
[quote]What have red wine studies found?

The cell and animal studies of red wine have examined effects in several cancers including leukemia, skin , breast, and prostate cancers . Scientists are studying resveratrol to learn more about its cancer preventive activities. Recent evidence from animal studies suggests this anti-inflammatory compound may be an effective chemopreventive agent in three stages of the cancer process: initiation, promotion, and progression.[/quote]
So I felt good about putting that red wine into my PEG tube. Then Morley Safer had a segment on the new Resveratrol pill with their scientists who explained it would take a THOUSAND BOTTLES OF WINE A DAY to get the dose they used for the above noted effects. Still it sounds very promising (big Pharm even bought out the start up company ) with projected availability in FIVE years until Morley pointed out that 9 out 10 drugs that cure cancer in mice do NOT work on humans.
I was going to post this in adjunctive therapy but right now it's not even ready for that forum then I did have a question that maybe the resourceful people here may give me a lead.
QUESTION: Human trials are supposed to be starting and I was wondering if any of you know tips or tricks to get into a study like this? Is there a clearinghouse for these early studies (I know about studies of already approved drugs like Erbitux but this is not FDA approved )thanks
Charm


65 yr Old Frack
Stage IV BOT T3N2M0 HPV 16+
2007:72GY IMRT(40) 8 ERBITUX No PEG
2008:CANCER BACK Salvage Surgery
25GY-CyberKnife(5) 3 Carboplatin
Apaghia /G button
2012: CANCER BACK -left tonsilar fossa
40GY-CyberKnife(5) 3 Carboplatin

Passed away 4-29-13
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Why not just carry out your own study and submit the results to them charm.It will save a lot of money lol


Liz in the UK

Husband Robin aged 44 years Dx 8th Dec 2006 poorly differentiated SCC tongue with met to neck T1N2cM0 Surgery and Radiation.Finished TX April 2007
Recurrence June/07 died July 29th/07.

Never take your eye off the ball, it may just smack you in the mouth.
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I should have made it clear: I mean the study by the producers of the synthetic Reservatrol pill on TV , NOT a Mexican clinic or Texas "clinical study" group or any of the other bogus cure or treatment places even if they are using some kind of red wine or polyphenol or other antioxidant variant. Zero interest in wasting time and money on frauds
Typing this out and posting it has helped me already as it dawned on me that I can send an e-mail to 60 minutes to ask for more info. But maybe someone out there knows someone in the loop?


65 yr Old Frack
Stage IV BOT T3N2M0 HPV 16+
2007:72GY IMRT(40) 8 ERBITUX No PEG
2008:CANCER BACK Salvage Surgery
25GY-CyberKnife(5) 3 Carboplatin
Apaghia /G button
2012: CANCER BACK -left tonsilar fossa
40GY-CyberKnife(5) 3 Carboplatin

Passed away 4-29-13
Joined: Mar 2008
Posts: 3,082
Patient Advocate (old timer, 2000 posts)
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Liz
Only if you will join me Birthday girl wink
But I like the idea - although I will need a bigger PEG tube.
charm


65 yr Old Frack
Stage IV BOT T3N2M0 HPV 16+
2007:72GY IMRT(40) 8 ERBITUX No PEG
2008:CANCER BACK Salvage Surgery
25GY-CyberKnife(5) 3 Carboplatin
Apaghia /G button
2012: CANCER BACK -left tonsilar fossa
40GY-CyberKnife(5) 3 Carboplatin

Passed away 4-29-13
Joined: May 2007
Posts: 666
"Above & Beyond" Member (500+ posts)
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Charm

there are several human trials underway and beginning (at least one P1 is finished)

here are a few links to keep you busy.
http://www.cancer.gov/clinicaltrials/CCUM-2004-0535
Phase I trial completed.... published results
97th Annual Meeting, April 1-5, 2006, Washington, DC. 2006
THAT is a bit thin... just an abstract at a meeting??

More interesting:
http://clinicaltrials.gov/ct2/results?intr=%22Protective+Agents%22
->refine search Resveratrol

M



Partial glossectomy (25%) anterior tongue. 4/6/07/. IMRT start @5/24/07 (3x) Erbitux start/end@ 5/24/07. IMRT wider field (30x) start 6/5/07. Weekly cisplatin (2x30mg/m2), then weekly carbo- (5x180mg/m2). End of Tx 19 July 07.
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Marcus

Thanks for the pointers. Lead me to clinicaltrials.gov where 10 studies popped up but none applicable (colon cancer, colorectal cancer, follicualar lymphoma ) plus the completed one you found for "healthy participants with zero history of cancer in 5 years"
Also found a Jan 2009 blog on the same 60 minutes show I saw last night - It was a repeat as it turns out !!! so very old news just recycled. It did have the company name so I can follow up. Thanks
Charm


65 yr Old Frack
Stage IV BOT T3N2M0 HPV 16+
2007:72GY IMRT(40) 8 ERBITUX No PEG
2008:CANCER BACK Salvage Surgery
25GY-CyberKnife(5) 3 Carboplatin
Apaghia /G button
2012: CANCER BACK -left tonsilar fossa
40GY-CyberKnife(5) 3 Carboplatin

Passed away 4-29-13
Joined: May 2007
Posts: 666
"Above & Beyond" Member (500+ posts)
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Charm,
it is difficult to find exactly what you want. I also have not found anything with resveratrol and oral cancer with respect to ongoing trials.

Perhaps we have to do our very own personal trial with the occasional glass or red wine.....

BTW to "fuel" the above argument
http://www.ncbi.nlm.nih.gov/pubmed/10211549
(note of caution this was JUST a cell line study, and once you ingest the wine you will of course greatly dilute the substance.... but still.


M




Partial glossectomy (25%) anterior tongue. 4/6/07/. IMRT start @5/24/07 (3x) Erbitux start/end@ 5/24/07. IMRT wider field (30x) start 6/5/07. Weekly cisplatin (2x30mg/m2), then weekly carbo- (5x180mg/m2). End of Tx 19 July 07.
Joined: Mar 2008
Posts: 3,082
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Marcus

thanks. While I know opinions vary on the wisdom of ingesting alcohol if you had oral cancer, all the concerns I saw dealt with it's deleterious effects on the mouth tissue. I almost forgot to add this argument in favor of the PEG to one of our new members. I just finished pouring a bolus of red wine into my PEG for dinner to accompany the Jevity 1.5. Luckily box wine works just fine (but be sure it is the box wine with real wine the same as would be in the company's bottles as opposed to those of just grain alcohol and grape juice). so now I have potentially a clinical trial of you. Liz and me. wink
charm


65 yr Old Frack
Stage IV BOT T3N2M0 HPV 16+
2007:72GY IMRT(40) 8 ERBITUX No PEG
2008:CANCER BACK Salvage Surgery
25GY-CyberKnife(5) 3 Carboplatin
Apaghia /G button
2012: CANCER BACK -left tonsilar fossa
40GY-CyberKnife(5) 3 Carboplatin

Passed away 4-29-13
Joined: May 2007
Posts: 666
"Above & Beyond" Member (500+ posts)
Offline
"Above & Beyond" Member (500+ posts)

Joined: May 2007
Posts: 666
Charm,
well in that case I serve as the non PEG control together with Liz. As I wrote in another post alcohol is not = alcohol. It will depend on the % and how long and much you keep in your mouth. The effect (acetaldehyde production which is the carcinogen) is local and dependent on the local uptake by the cells (and their metabolism) and therefore in the contact time. So lower % alcohol seems better than higher %. With that logic (!) drink quickly then rinse your mouth with water.... (or use a PEG)
I am not aware of any hard data supporting the opinion above, it seems logical but that does not prove it.

In any case I personally am not worried about an occasional glass or two (wine) on the weekend.


M




Partial glossectomy (25%) anterior tongue. 4/6/07/. IMRT start @5/24/07 (3x) Erbitux start/end@ 5/24/07. IMRT wider field (30x) start 6/5/07. Weekly cisplatin (2x30mg/m2), then weekly carbo- (5x180mg/m2). End of Tx 19 July 07.
Joined: Jun 2009
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My husband starts Erbitux July 7 and was told to stop taking the Reversatrol capsules he has been taking for the last month since they might react with the Erbitux. I told him to go ahead and take it during Chemo. It has helped his energy and sexuality greatly since beginning Reversatrol and I can't help but think it will also help him through the Chemo and radiation regimen.

Sandy


Husband 79 metastatic cancer neck lymph nodes, biopsy Moffitt showed base of tongue, tonsil & vallecula. VA in Tampa - Teeth out 6/16, Radiation 5X7 and Erbitux 7/13 Carboplatin 8/4 - Amifostine added 8/6

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