#38815 07-14-2005 02:14 AM | Joined: Jun 2005 Posts: 25 Contributing Member (25+ posts) | OP  Contributing Member (25+ posts)
Joined: Jun 2005 Posts: 25 | Just wondering if anyone on this forum from Canada or Europe has used Benzydamine as a mouthwash to combat mucositis. It is available there but not here yet. A recent survey of treatments for oral mucositis said that this product, as well as GelClair and a drug currently in trial (L-Glutamine AES-14) were superior to any other materials (including "magic mouthwash" which did not appear to be so very magic for most people) in alleviating OM.
Barry Cooper | | |
#38816 07-20-2005 08:47 AM | Joined: Jul 2005 Posts: 624 "Above & Beyond" Member (500+ posts) | | "Above & Beyond" Member (500+ posts)
Joined: Jul 2005 Posts: 624 | I am surprised that no one responded to this post -- Benzydamine was written up in a recent review paper as the only material that showed significant effect on both preventing and alleviating severe mucositis in HNC patients recieving radiation, compared to a placebo in a clinical trial. It is used (as a oral wash) before radiation begins and 3-4x daily throughout.
Unfortunately it is not yet available in the USA, but is in Canada as a prescription drug (Tantum), and OTC in UK, much of the rest of Europe and Australia/NZ (Difflam).
I would also be interested to hear if anyone from these countries was given benzydamine and if it helped.
Gail
CG to husband Barry, dx. 7/21/05, age 66, SCC rgt. tonsil, BOT, 2 nodes (stg. IV), HPV+, tonsillectomy, 7x carboplatin, 35x tomoTherapy IMRT w/ Ethyol @ Johns Hopkins, thru treatment 9/28/05, HPV vaccine trial 12/06-present. Looking good!
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#38817 07-20-2005 02:55 PM | Joined: Nov 2002 Posts: 3,552 Patient Advocate (old timer, 2000 posts) | | Patient Advocate (old timer, 2000 posts)
Joined: Nov 2002 Posts: 3,552 | Gail,
it's not avaiable in the US and that's probably why no one responded. I saw the report as well and it's probably in the news section of the site. Sounds very promising.
Gary Allsebrook
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Dx 11/22/02, SCC, 6 x 3 cm Polypoid tumor, rt tonsil, Stage III/IVA, T3N0M0 G1/2
Tx 1/28/03 - 3/19/03, Cisplatin ct x2, IMRT, bilateral, with boost, x35(69.96Gy)
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"You are a mist that appears for a little while and then vanishes" (James 4:14 NIV)
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#38818 07-21-2005 12:45 AM | Joined: Jul 2005 Posts: 624 "Above & Beyond" Member (500+ posts) | | "Above & Beyond" Member (500+ posts)
Joined: Jul 2005 Posts: 624 | Yes, it sounds very interesting -- I just knew we have some forum members from UK and so thought they might have been given this medication and could give us a report.
It is a non-steroidal antinflammatory and perhaps FDA is being a bit cautious as they have been burned recently on Vioxx and Bextra. However it is not ingested and all the material I have read seems to be almost no side effects unless it is accidentally swallowed.
The major difference from all the other stuff used for mucositis is that it should be started before treatment begins as it is also prophylactic.
Since mucositis can be serious in and of itself, and can lead to treatment delays which reduce effectiveness, this kind of medication is really needed. There is another med in trial, Aesgen, which is a l-glumatine formulation which greatly enhances uptake of the amino acid and provides protection and relief. Unfortunately, still "in the pipeline" too!
Gail
CG to husband Barry, dx. 7/21/05, age 66, SCC rgt. tonsil, BOT, 2 nodes (stg. IV), HPV+, tonsillectomy, 7x carboplatin, 35x tomoTherapy IMRT w/ Ethyol @ Johns Hopkins, thru treatment 9/28/05, HPV vaccine trial 12/06-present. Looking good!
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