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#158986 - 12/15/12 04:24 AM Study
Brian Hill Offline
OCF Founder
Patient Advocate (old timer, 2000 posts)

Registered: 03/18/02
Posts: 4665
Loc: Laguna Niguel, CA
This is really for David and a couple of the other science nerds here. It is part of a huge multinational HPV study, this component heavily contributed to by OCF science board member Dr. Maura Gillison. This is not light reading.

http://www.oralcancerfoundation.org/hpv/pdf/Human-Papillomavirus-Diseases-Upper-Airway-2012.pdf
_________________________
Brian, stage 4 oral cancer survivor. OCF Founder and Director. The first responsibility of a leader is to define reality. The last is to say thank you. In between, the leader is a servant.

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#158999 - 12/15/12 05:08 PM Re: Study [Re: Brian Hill]
David2 Offline
Patient Advocate (1000+ posts)

Registered: 07/12/09
Posts: 1262
Loc: Los Angeles
Hoping to catch a little of the reflected intellectual light off my namesake's acumen I'll have a look at it too, Brian. But on first glance I must say it looks daunting. I can't even pronounce the names of the authors.
_________________________
David 2
SCC of occult origin 1/09 (age 55)| Stage II TXN1M0 | HPV 16+, non-smoker, moderate drinker | Modified radical neck dissection 3/09 | 31 days IMRT finished 6/09 | Hit 5 years all clear in 6/14

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#159017 - 12/16/12 05:50 AM Re: Study [Re: Brian Hill]
klo Offline
"OCF Down Under"
"Above & Beyond" Member (500+ posts)

Registered: 05/18/10
Posts: 638
Loc: Sydney Australia
Well, I have read it - took me an hour and a half. Very dry!

I have filed the article because it is a nice review of everything we know so far and the statistics are interesting (to me anyway).

In terms of practical use on this forum (ie which treatment should be used, how to manage side effects etc) it won't answer your questions, so I would recommend that unless you are a person who likes statistics, or are going into battle with the various regulatory agencies and payors, you might be best using the hour and a half doing something else.

It IS a great index for every reference to every major paper I have ever read though and this is also a reason for filing it.
_________________________
Karen
Love of Life to Alex T4N2M0 SCC Tonsil, BOT, R lymph nodes
Dx March 2010 51yrs. Unresectable. HPV+ve
Tx Chemo x 3+1 cycles(cisplatin,docetaxel,5FU)- complete May 31
Chemoradiation (IMRTx35 + weekly cisplatin)
Finish Aug 27
Return to work 2 years on
3 years out Aug 27 2013 NED smile
Still underweight

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#159026 - 12/16/12 02:59 PM Re: Study [Re: Brian Hill]
davidcpa Offline

Administrator, Senior Patient Advocate
Patient Advocate (old timer, 2000 posts)

Registered: 09/28/06
Posts: 8309
Loc: Gulfport, Florida
Karen,

Can you give me the Cliffsnotes version? lol

Dry.....you should read some tax law articles I have to read!
_________________________
David

Age 58 at Dx, HPV16+ SCC, Stage IV BOT+2 nodes, non smoker, casual drinker, exercise nut, Cisplatin x 3 & concurrent IMRT x 35,(70 Gy), no surgery, no Peg, Tx at Moffitt over Aug 06. Jun 07, back to riding my bike 100 miles a wk. Now doing 12 Spin classes and 60 outdoor miles per wk. Nov 13 completed Hilly Century ride for Cancer, 104 miles, 1st Place in my age group. Apr 14, Spun for 9 straight hrs to raise $$ for YMCA's Livestrong Program. Certified Spin Instructor Jun 2014.

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#159027 - 12/16/12 03:00 PM Re: Study [Re: Brian Hill]
davidcpa Offline

Administrator, Senior Patient Advocate
Patient Advocate (old timer, 2000 posts)

Registered: 09/28/06
Posts: 8309
Loc: Gulfport, Florida
Brian,

Thanks for always keeping me abreast.
_________________________
David

Age 58 at Dx, HPV16+ SCC, Stage IV BOT+2 nodes, non smoker, casual drinker, exercise nut, Cisplatin x 3 & concurrent IMRT x 35,(70 Gy), no surgery, no Peg, Tx at Moffitt over Aug 06. Jun 07, back to riding my bike 100 miles a wk. Now doing 12 Spin classes and 60 outdoor miles per wk. Nov 13 completed Hilly Century ride for Cancer, 104 miles, 1st Place in my age group. Apr 14, Spun for 9 straight hrs to raise $$ for YMCA's Livestrong Program. Certified Spin Instructor Jun 2014.

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#159037 - 12/16/12 05:16 PM Re: Study [Re: davidcpa]
Charm2017 Offline
Patient Advocate (old timer, 2000 posts)

Registered: 03/03/08
Posts: 3082
Loc: Alexandria VA
I have to go with DavidCPA on how tax articles and regulations are a lot dryer and complicated than Gillison's study. Especially since you can just read the abstract and get the major points. If you take your time and read it, Gillison's study is well written and understandable. Not so with tax regulations which have multiple subsections and often assume you know the other subsections which they refer to with zero explanation (I'm biased after arguing for over 20 years with the IRS attorneys who write those regs)

What is amazing to me is Gillison's adherence to giving both sides of the argument, marshalling in one place the conflicting studies. If everything does not line up, she says it needs more investigating, like the links between tobacco & alcohol on HPV (unproven either way). So when she does say something, you can count on it like: HPV causes oral cancer in both users and non users of tobacco and alchohol.

But the biggest comfort to me is her conclusion, stated in the abstract, that HPV + patients have at least a 50% improvement in overall survival at 5 years which is equivalent to a 30% improvement in absolute survival.

Thanks Brian for putting this up both on the OCF web and forum
Charm


Edited by Charm2017 (12/16/12 05:17 PM)
Edit Reason: typos
_________________________
65 yr Old Frack
Stage IV BOT T3N2M0 HPV 16+
2007:72GY IMRT(40) 8 ERBITUX No PEG
2008:CANCER BACK Salvage Surgery
25GY-CyberKnife(5) 3 Carboplatin
Apaghia /G button
2012: CANCER BACK -left tonsilar fossa
40GY-CyberKnife(5) 3 Carboplatin

Passed away 4-29-13

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#159043 - 12/16/12 08:45 PM Re: Study [Re: Brian Hill]
klo Offline
"OCF Down Under"
"Above & Beyond" Member (500+ posts)

Registered: 05/18/10
Posts: 638
Loc: Sydney Australia
Quote:
Not so with tax regulations which have multiple subsections and often assume you know the other subsections which they refer to with zero explanation (I'm biased after arguing for over 20 years with the IRS attorneys who write those regs)


not to mention no commas, very few full stops (periods) and an awful lot of "and"s and "or"s smile

_________________________
Karen
Love of Life to Alex T4N2M0 SCC Tonsil, BOT, R lymph nodes
Dx March 2010 51yrs. Unresectable. HPV+ve
Tx Chemo x 3+1 cycles(cisplatin,docetaxel,5FU)- complete May 31
Chemoradiation (IMRTx35 + weekly cisplatin)
Finish Aug 27
Return to work 2 years on
3 years out Aug 27 2013 NED smile
Still underweight

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#159130 - 12/18/12 06:56 PM Re: Study [Re: Brian Hill]
David2 Offline
Patient Advocate (1000+ posts)

Registered: 07/12/09
Posts: 1262
Loc: Los Angeles
Charm, agreed on the Gillison piece. I read it and understood more than I thought I would. And certainly the conclusions you mention stand out.

As for tax law... many years ago in grad school they made us take a semester of it (I was studying arts administration). Even though the professor dumbed it down considerably for us artistic types, I still don't remember a word. Nor, as I recall, did I at the time.

I also took a semester of accounting (this for you David...) and here's what I remember: debits left, credits right. Hmm... or is it the other way around?
_________________________
David 2
SCC of occult origin 1/09 (age 55)| Stage II TXN1M0 | HPV 16+, non-smoker, moderate drinker | Modified radical neck dissection 3/09 | 31 days IMRT finished 6/09 | Hit 5 years all clear in 6/14

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#159263 - 12/21/12 08:15 AM Re: Study [Re: David2]
Penny_T Offline
Contributing Member (25+ posts)

Registered: 01/30/12
Posts: 27
Loc: CA
Is it sad that I actually enjoy reading about and researching tax law issues? I always look forward to my CPE courses. As it turns out, I now also enjoy reading studies and researching medical information.

In spite of all that, I am still quite a fun person! My friends and family looked at me like I was nuts when I changed my major to accounting. My boyfriend "Cool story, bro" s me when I start talking about work.
_________________________
33 yr old female, former smoker of too many years.
Currently awaiting results of a neck ultrasound.

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