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#151127 - 06/22/12 08:13 PM Cancer Evolution
Charm2017 Offline
Patient Advocate (old timer, 2000 posts)

Registered: 03/03/08
Posts: 3082
Loc: Alexandria VA


Edited by Charm2017 (06/22/12 08:16 PM)
Edit Reason: typos
_________________________
65 yr Old Frack
Stage IV BOT T3N2M0 HPV 16+
2007:72GY IMRT(40) 8 ERBITUX No PEG
2008:CANCER BACK Salvage Surgery
25GY-CyberKnife(5) 3 Carboplatin
Apaghia /G button
2012: CANCER BACK -left tonsilar fossa
40GY-CyberKnife(5) 3 Carboplatin

Passed away 4-29-13

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#151130 - 06/22/12 10:54 PM Re: Cancer Evolution [Re: Charm2017]
Maria Offline
"Above & Beyond" Member (500+ posts)

Registered: 07/15/11
Posts: 873
Loc: Ohio
I was especially interested in the Gardisil / Adverse effects story from Forbes - I read Science Daily ... um, daily but never would have picked uo the Forbes article. Great job, Brian and Sheldon!
_________________________
CG to husband - SCC Tonsil T1N2M0 HPV+ Never Smoker
First symptoms 7/2010, DX 12/2010
TX 40 IRMT (1.8 gy) + 10 Cetuximab
PET Scans 6/2011 + 3/2012 clear, 06/2014 physical exam clear; chest CT's clear of cancer. On thyroid pills. Saliva slowly returning. Life is good.

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#151131 - 06/23/12 12:09 AM Re: Cancer Evolution [Re: Charm2017]
Brian Hill Offline
OCF Founder
Patient Advocate (old timer, 2000 posts)

Registered: 03/18/02
Posts: 4670
Loc: Laguna Niguel, CA
While I read Forbes occasionally ( can't ditch my old business background), I have been communicating with Matt Herper for some time. He is the one science writer that comes to things in an unbiased, and very easy to understand manner. My favorite article of his had to do with Bill Gates and how his "outlier ideas" about the health problems in Africa, are completely changing our understanding of childhood deaths there, and what he is doing about it for not so much $ per life saved.

http://www.forbes.com/sites/matthewherper/2011/11/02/the-second-coming-of-bill-gates/

_________________________
Brian, stage 4 oral cancer survivor. OCF Founder and Director. The first responsibility of a leader is to define reality. The last is to say thank you. In between, the leader is a servant.

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#151139 - 06/23/12 10:56 AM Re: Cancer Evolution [Re: Charm2017]
Anne-Marie Offline
Patient Advocate (old timer, 2000 posts)

Registered: 11/03/06
Posts: 2594
Loc: TN
What a great article about Bill Gates and his ability to shift course in his thinking in order to solve problems! I wish more of our politicians had the same insight and ability.
_________________________
Anne-Marie
CG to son, Paul (age 33, non-smoker) SCC Stage 2, Surgery 9/21/06, 1/6 tongue Rt.side removed, +48 lymph nodes neck. IMRTx28 completed 12/19/06. CT scan 7/8/10 Cancer-free! ("spot" on lung from scar tissue related to Pneumonia.)




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#151141 - 06/23/12 11:24 AM Re: Cancer Evolution [Re: Charm2017]
klo Offline
"OCF Down Under"
"Above & Beyond" Member (500+ posts)

Registered: 05/18/10
Posts: 638
Loc: Sydney Australia
_________________________
Karen
Love of Life to Alex T4N2M0 SCC Tonsil, BOT, R lymph nodes
Dx March 2010 51yrs. Unresectable. HPV+ve
Tx Chemo x 3+1 cycles(cisplatin,docetaxel,5FU)- complete May 31
Chemoradiation (IMRTx35 + weekly cisplatin)
Finish Aug 27
Return to work 2 years on
3 years out Aug 27 2013 NED smile
Still underweight

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#151155 - 06/23/12 02:42 PM Re: Cancer Evolution [Re: Brian Hill]
David2 Offline
Patient Advocate (1000+ posts)

Registered: 07/12/09
Posts: 1266
Loc: Los Angeles
Excellent article, Brian. Thanks for posting it - I never would have known about it otherwise.
_________________________
David 2
SCC of occult origin 1/09 (age 55)| Stage II TXN1M0 | HPV 16+, non-smoker, moderate drinker | Modified radical neck dissection 3/09 | 31 days IMRT finished 6/09 | Hit 5 years all clear in 6/14

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#151158 - 06/23/12 02:57 PM Re: Cancer Evolution [Re: Charm2017]
Maria Offline
"Above & Beyond" Member (500+ posts)

Registered: 07/15/11
Posts: 873
Loc: Ohio
Trial design is much more straightforward if you are looking at one factor at a time - the addition (or not) of a single chemo agent, or the radiotherapy fractionation protocol. If you design a trial that has multiple factors, it's harder to tell definatively which tweek gave better results, or if it was the combination that did it. Science Daily had another article that explains a combination. It is way pre-clinical (unless you are a fruit fly) but very interesting and less depressing that the cancer and the Darwinian cancer evolution one:

http://www.sciencedaily.com/releases/2012/06/120615141716.htm

Maria
_________________________
CG to husband - SCC Tonsil T1N2M0 HPV+ Never Smoker
First symptoms 7/2010, DX 12/2010
TX 40 IRMT (1.8 gy) + 10 Cetuximab
PET Scans 6/2011 + 3/2012 clear, 06/2014 physical exam clear; chest CT's clear of cancer. On thyroid pills. Saliva slowly returning. Life is good.

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#151436 - 06/29/12 01:09 PM Re: Cancer Evolution [Re: Maria]
Charm2017 Offline
Patient Advocate (old timer, 2000 posts)

Registered: 03/03/08
Posts: 3082
Loc: Alexandria VA
Here is another piece of the "evolution" puzzle from a news release from John Hopkins Kimmel Cancer Center when its "Kimmel wire" email news service sent me this excerpt yesterday:
Quote:
Targeted cancer cell therapies using man-made proteins dramatically shrink many tumors in the first few months of treatment, but new research from Johns Hopkins scientists finds why the cells all too often become resistant, the treatment stops working, and the disease returns.

As you can see from the full news release, it is about colon cancer and there is no proof that it would apply to oral cancer- I want to make that clear - although I do believe it does raise a hypothesis worth exploring for oral cancer patients. Hopkins news release
As noted in this thread, right now using a combination of therapies looks promising.
charm


Edited by Charm2017 (06/29/12 01:13 PM)
Edit Reason: typos
_________________________
65 yr Old Frack
Stage IV BOT T3N2M0 HPV 16+
2007:72GY IMRT(40) 8 ERBITUX No PEG
2008:CANCER BACK Salvage Surgery
25GY-CyberKnife(5) 3 Carboplatin
Apaghia /G button
2012: CANCER BACK -left tonsilar fossa
40GY-CyberKnife(5) 3 Carboplatin

Passed away 4-29-13

Top
#151437 - 06/29/12 03:16 PM Re: Cancer Evolution [Re: Charm2017]
Maria Offline
"Above & Beyond" Member (500+ posts)

Registered: 07/15/11
Posts: 873
Loc: Ohio
Resistance to drugs is a huge issue. There is a whole journal devoted to drug resistance -

http://www.drupjournal.com/home

It includes recent work on EFGR targeted resistance in HNSCC - I can only get at the abstracts on my login. I stumbled on the journal trying to find references to recent work by Posner and Bonner. Will try to post the best links for these this weekend.
_________________________
CG to husband - SCC Tonsil T1N2M0 HPV+ Never Smoker
First symptoms 7/2010, DX 12/2010
TX 40 IRMT (1.8 gy) + 10 Cetuximab
PET Scans 6/2011 + 3/2012 clear, 06/2014 physical exam clear; chest CT's clear of cancer. On thyroid pills. Saliva slowly returning. Life is good.

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