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Actually the big HPV's in cervical cancer are 16 and 18, and in the mouth it is primarily 16. There is a distinct clinically proven survival advantage to HPV+ disease in the mouth vs tobacco origin disease, (as others have stated above) and this is likely because it seems to respond better to radiation. So that survival advantage has NOT been proven in patients that do NOT have multidisciplinary treatments that omit radiation.

Last edited by Brian Hill; 03-16-2012 11:03 AM.

Brian, stage 4 oral cancer survivor. OCF Founder and Director. The first responsibility of a leader is to define reality. The last is to say thank you. In between, the leader is a servant.
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Oh....and definately listen to what Brian says as well as to the other senior members here on OCF. I learned a lot while going through my journey with cancer but these are the folks who REALLY know their stuff. (Hi Brian smile

Will


Lump in left side neck discovered Sept 2009
Misdiagnosed & FNA inconclusive
Large lymph node removed Nov. 2010 SCC and HPV16 pos
PET pointed tonsilectomy Feb. 2011
1ml tumor left side tonsil
Rads scheduled March 14th 2011. 2X36 GY's (72)
CarboTaxol once a week X 4 or 5 starting 4/5/11
No PEG
Joined: Oct 2011
Posts: 805
KP5 Offline
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Not true. Cervical cancer is HPV 16 too. At least they told me that's what mine is, unfortunately! The HPV that causes warts is not though.

Last edited by KP5; 03-16-2012 01:39 PM.

Kathy wife/caregiver to:
Kevin age:53
Dx 7/15/11
HPV16+ SCC Stage IV BOT/R
Non smoker, casual drinker
7/27/11 Cistplatin, taxotere,5FU 2/3week sessions, followed by IMRT 125cgy x 60 (2x daily) w/Erbitux weekly. Last rad 10/26/11. Last Erbitux 10/27/11
PEG placed 9/1/11 Removed 11/8/11
Clear PET 10/12 and 10/13 and ct in 6/14
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Posts: 1,844
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Kathy, you may not have read Brian's post correctly. "Actually the big HPV's in cervical cancer are 16 and 18"


Young Frack, SCC T4N2M0, Cisplatin,35+ rads,ND, RT Mandiblectomy w fibular free flap, facial paralysis, "He who has a "why" to live can bear with almost any "how"." -Nietzche "WARNING" PG-13 due to Sarcasm & WAY too much attitude, interact at your own risk.
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KP5 Offline
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I was actually responding to what Mainewill said about cervical cancer not being HPV 16. I hadn't seen Brian's or the others at the time. Oops I guess.


Kathy wife/caregiver to:
Kevin age:53
Dx 7/15/11
HPV16+ SCC Stage IV BOT/R
Non smoker, casual drinker
7/27/11 Cistplatin, taxotere,5FU 2/3week sessions, followed by IMRT 125cgy x 60 (2x daily) w/Erbitux weekly. Last rad 10/26/11. Last Erbitux 10/27/11
PEG placed 9/1/11 Removed 11/8/11
Clear PET 10/12 and 10/13 and ct in 6/14
Joined: Mar 2011
Posts: 130
Likes: 3
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Well don't I feel like a dummy. I was going on what my RO told me about the strains. This is a reminder to me that in most cases the folks here on the OCF are far more helpful with information that medical professionals. Glad to be back and cancer free.

Will


Lump in left side neck discovered Sept 2009
Misdiagnosed & FNA inconclusive
Large lymph node removed Nov. 2010 SCC and HPV16 pos
PET pointed tonsilectomy Feb. 2011
1ml tumor left side tonsil
Rads scheduled March 14th 2011. 2X36 GY's (72)
CarboTaxol once a week X 4 or 5 starting 4/5/11
No PEG
Joined: Oct 2011
Posts: 805
KP5 Offline
"Above & Beyond" Member (500+ posts)
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"Above & Beyond" Member (500+ posts)

Joined: Oct 2011
Posts: 805
Sadly it's cuz we are living it!! So encouraged by your cancer free. I have family in Brunswick and Nobleboro and some in between. LOVE Maine.


Kathy wife/caregiver to:
Kevin age:53
Dx 7/15/11
HPV16+ SCC Stage IV BOT/R
Non smoker, casual drinker
7/27/11 Cistplatin, taxotere,5FU 2/3week sessions, followed by IMRT 125cgy x 60 (2x daily) w/Erbitux weekly. Last rad 10/26/11. Last Erbitux 10/27/11
PEG placed 9/1/11 Removed 11/8/11
Clear PET 10/12 and 10/13 and ct in 6/14
Joined: Jan 2012
Posts: 21
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Posts: 21
Hi Will, thanks for the info. Would you be available to talk to my doctors?! ha, ha. - because I seem to get NO where with them as far as my HPV status. They have basically blown me off and said it doesn't matter and it wouldn't change anything????? If you could tell me a little more about what P16 driven and BCL2 marker mean, I would sure appreciate the info! I've been doing my own research but sometimes it feels like my head is going to start spinning and I don't understand half of what I read. frown

Thanks!


1/10/12 laryngoscopy
1/12/12 diagnosed with laryngeal cancer (T1N0M0) HPV+
2/1/12 had partial laryngectomy
2/7/12 post op appt. surgery seems to be a success (no other treatment needed). Praise God! smile smile smile
3/20/12 6 week follow up. all seems to be well
Joined: May 2010
Posts: 638
klo Offline
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Posts: 638
Hi Annie

Alex and I had exactly the same battle with our oncologists and they gave the same excuse for not doing it as yours did. I ended up emailing the most senior one, making the following points
a) agree that HPV status makes no difference to treatment today
b) however, that is likely to be because we still don't know exactly what makes HPV different and respond better to treatment
c) who knows, in the future treatment of an HPV positive cancer may well be different to other cancers and I would be devastated if, in the event of a recurrence, I couldn't make the correct decision because Alex had never been tested (or in your case, not given the information about which type of HPV it was)
d) Alex and I have decided that we would definitely like this information for the future and would be grateful if Dr T could arrange this for us (gave him no choice)

They tested the original biopsy sample so Alex didn't even have to do anything.

A week later we were found to be HPV +ve and whilst it didn't change our treatment, it made Dr T start paying attention when Alex had a dramatic response - first to chemotherapy and then to chemoradiation!

Our cancer co-ordinator bailed me up during one of Alex's treatment sessions a few weeks later to ask me to share what I knew about HPV and oral cancer as Dr T had asked for testing on another 6 patients with similar diagnosis.

I thought that was a pretty big win and I remind Alex of this incident when he momentarily forgets my goddess status smile.

Karen
PS we did not get tested for the actual HPV virus as such but were tested for a marker of HPV type 16 which according to my reading, is a pretty good surrogate (on shaky ground here so unable to explain any better).


Karen
Love of Life to Alex T4N2M0 SCC Tonsil, BOT, R lymph nodes
Dx March 2010 51yrs. Unresectable. HPV+ve
Tx Chemo x 3+1 cycles(cisplatin,docetaxel,5FU)- complete May 31
Chemoradiation (IMRTx35 + weekly cisplatin)
Finish Aug 27
Return to work 2 years on
3 years out Aug 27 2013 NED smile
Still underweight
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