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#144920 01-22-2012 12:05 PM
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Last edited by Brian Hill; 01-31-2012 10:24 PM. Reason: unverifiable information
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I searched the National Cancer Institute website for clinical trials that might pertain to this - found nothing. Maybe someone will have better luck. Unfortunately, the author mentions nothing readily identifiable in the article.


CG to husband - SCC Tonsil T1N2M0 HPV+ Never Smoker
First symptoms 7/2010, DX 12/2010
TX 40 IRMT (1.8 gy) + 10 Cetuximab
PET Scans 6/2011 + 3/2012 clear, 5 year physical exam clear; chest CT's clear of cancer. On thyroid pills. Life is good.
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If you go to the main page of OCF, click the search box upper right and type in "Immunotherapy" this comes up:

http://www.oralcancerfoundation.org/searchresults.htm?cx=015422755131303034108%3Ao3fylifwmag&cof=FORID%3A11&q=Immunotherapy&sa=Search
The article mentions that -
<<Biological therapy (sometimes called immunotherapy)>>

Hope this helps -


Last edited by Anne-Marie; 01-31-2012 04:44 AM. Reason: added quote re biological therapy.

Anne-Marie
CG to son, Paul (age 33, non-smoker) SCC Stage 2, Surgery 9/21/06, 1/6 tongue Rt.side removed, +48 lymph nodes neck. IMRTx28 completed 12/19/06. CT scan 7/8/10 Cancer-free! ("spot" on lung from scar tissue related to Pneumonia.)



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Also you can pm the original poster directly !


Cheryl : Irritation - 2004 BX: 6/2008 : Inflam. BX: 12/10, DX: 12/10 : SCC - LS tongue well dif. T2N1M0. 2/11 hemigloss + recon. : PND - 40 nodes - 39 clear. 3/11 - 5/11 IMRT 33 + cis x2, PEG 3/28/11 - 5/19/11 3 head, 2 chest scans - clear(fingers crossed) HPV-, No smoke, drink, or drugs, Vegan
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I would appreciate it if people would refrain from putting up articles from general news sources that have no trial attribution, no names of the primary investigators, institutions, agencies, the funders of the trial etc. in them. We have no way of knowing what this is, if it is bogus or whatever. There isn't a piece of traceable information in the story.

These kinds of things need to be passed by the admins first so we can locate the trial for you (if there is one). More than that with many people gleaning the clinical trial register and hundreds of other sources for important oral cancer news, anything of value that can be verified appears daily on the OCF news feed which you should all subscribe to if you are really that interested in staying up to date on everything. It's FREE.


Brian, stage 4 oral cancer survivor. OCF Founder and Director. The first responsibility of a leader is to define reality. The last is to say thank you. In between, the leader is a servant.
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Brian

Thanks for keeping the forum based on facts not wishful thinking. I've been intrigued by Immunotherapy and have seen the writeups on the American Cancer Society web site and other medical journals. They uniformly conclude that while the idea of using one's own immune system to fight cancer is tempting, so far, immunotherapy hasn't been shown to work on oral cancer although it is being tested on some other cancers.
It's important that people who turn to OCF not think there is really any alternative to radiation, chemo and surgery at this time, if they want to survive. Thank you
Charm

Last edited by Charm2017; 02-01-2012 08:11 AM. Reason: typos

65 yr Old Frack
Stage IV BOT T3N2M0 HPV 16+
2007:72GY IMRT(40) 8 ERBITUX No PEG
2008:CANCER BACK Salvage Surgery
25GY-CyberKnife(5) 3 Carboplatin
Apaghia /G button
2012: CANCER BACK -left tonsilar fossa
40GY-CyberKnife(5) 3 Carboplatin

Passed away 4-29-13
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Some of the new possibilities with cancer treatment are in the very pre-clinical stages, using mouse models or cells in a petri dish. Many of these (like the grape seed extract) are VERY encouraging for the future - but only some of these will pan out in actual human patients.


CG to husband - SCC Tonsil T1N2M0 HPV+ Never Smoker
First symptoms 7/2010, DX 12/2010
TX 40 IRMT (1.8 gy) + 10 Cetuximab
PET Scans 6/2011 + 3/2012 clear, 5 year physical exam clear; chest CT's clear of cancer. On thyroid pills. Life is good.
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OK, here is the story with a link to the real research article for those so inclined. I put in the OCF news feed today as well.

http://oralcancernews.org/wp/queensland-researchers-make-cancer-treatment-breakthrough/


Brian, stage 4 oral cancer survivor. OCF Founder and Director. The first responsibility of a leader is to define reality. The last is to say thank you. In between, the leader is a servant.
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The article states that NP cancer is related to the Epstein Barr Virus (EPV) which gives this immunotherapy a target
[quote]�The presence of EBV in the cancer cells gives the body�s immune system a definite target to help battle the NPC, resulting in few side-effects,� Professor Khanna said.[/quote]

I get the possible future application on targeting HPV in a similar manner but most drugs or therapy that work on one virus don't work very well on another virus. I noticed that the doctor was also careful to note that he saw the future application of this immunotherapy to be as an adjunct to concurrent radiation and chemotherapy.
While I knew that EBV caused NP cancer as well as mononucleosis, my understanding was that it's not genetically significant for any other head and neck cancer patients. According to this NIH Medline study from 2004:.
[quote]In the overwhelming majority of head and neck cancers in this North American cohort, EBV did not appear to contribute to growth of a dominant clonal population with integrated EBV genome and was unlikely to be a genetic etiological agent in tumor development. The low quantities of EBV detected in a minority of head and neck cancers may be related to the presence of EBV genome in rare lymphoid or epithelial cells adjacent to the primary head and neck cancer
[/quote] NIH: EBV-head & neck cancer
So IMO, it's undoubtedly a breakthru for NP but not yet for the rest of our cancers.
Charm


Last edited by Charm2017; 02-02-2012 09:42 AM. Reason: typos

65 yr Old Frack
Stage IV BOT T3N2M0 HPV 16+
2007:72GY IMRT(40) 8 ERBITUX No PEG
2008:CANCER BACK Salvage Surgery
25GY-CyberKnife(5) 3 Carboplatin
Apaghia /G button
2012: CANCER BACK -left tonsilar fossa
40GY-CyberKnife(5) 3 Carboplatin

Passed away 4-29-13
Joined: Jul 2011
Posts: 945
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Charm noted:

"most drugs or therapy that work on one virus don't work very well on another virus."

True - but the body of knowledge, techniques and equipment that got to that breakthrough is now available to researchers in related fields. And it's ecouraging to those working in the field: doctors aren't fond of having to nearly do in their patients with the treatment to have a decent chance of a cure.

Here's another encouraging story on Science Daily - a new methodology for in vitro studies of cancer:

http://www.sciencedaily.com/releases/2012/01/120111103906.htm

Last edited by Maria; 02-02-2012 10:19 AM.

CG to husband - SCC Tonsil T1N2M0 HPV+ Never Smoker
First symptoms 7/2010, DX 12/2010
TX 40 IRMT (1.8 gy) + 10 Cetuximab
PET Scans 6/2011 + 3/2012 clear, 5 year physical exam clear; chest CT's clear of cancer. On thyroid pills. Life is good.
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