Does anyone know if after HPV-16 positive diagnosis and then radiation or radiation and chemo treatment for oral cancer, if we should in reality expect the virus is still in our bodies and subject to being transmited via kissing or other sexual contact.

I've heard lots of opinions in other peoples threads. It seems it would be better for all of us if we could get all that information here in one thread.

I would be interested in this thread becoming the definitive thread for discussion of HPV-16 on this forum.

Likewise I would like to see any URL references to published studies on the subject.

I know this forum is about oral cancer and it's treatment, and not a forum about getting our love life back on track after treatment. But since I expect this forum has the most up to date technical information about the virus on the internet , that makes it also the most appropriate place to discuss exactly this issue.

Other opinions?

thanks guys,

Tony

I've asked about this a few times.

The answer is yes, it's still active and can still be transmitted. Talking with my MO he says most people have already been exposed by the time they are in their twenties. Contracted and cleared no additional risk from exposure.

So my wife has been exposed and has cleared the virus most likely over the years. So no need for additional precautions. I would have the discussion with anyone else to be up front.

My concern also was I have cancer from this virus so even if I remain cancer free for 5 years what is there to keep the virus from initiating a new cancer? My MO says nothing. He said I will continue to be checked regularly so if it starts new we'll find it quickly. Not comforting.

John

The topic of HPV and oral cancer are deeply intertwined and trying to corral all posts related to HPV into one thread is admirable but won't happen. Many people are not going to search for this specific thread then post in it. Also, one thread that gets loaded with hundreds of posts is almost useless from a practical point in terms of someone wading through the whole thing. Some may do that but the vast majority do not have the time. Using the search function can bring results back.

The way HPV works is most all adults who have sex have likely gotten the virus and passed it. For those who harbor the virus it may hide out for many years, even decades, then might turn into cancer.

If one is 30 something and diagnosed with HPV+ cancer and has partners of similar age, then there is more validity to informing partners about the potential risks. If one is sixty something and partners of the same vintage, then my view is why bother saying anything. At this point, many decades have come and gone and the body has passed it and immune to it, or it has rooted itself in hiding and waiting to become cancer or remain there. Nothing you do at this point is going to either make the situation better or worse.

Don

So there re several HPV threads running on the forum in the last month. Some are really long, and drawn out with lots of opinions and ideas. I am just going to post here on this recent short one (sorry for not being specific about the exact question asked), to make sure that those that are looking for studies know that OCF has captured with the authors permission, or they were studies that our donors sponsored portions of, and the most relevant ones are right here on our site. For sure there are others, but some have inherent bias in them, small populations, or done without proper scientific controls, and they were culled from what our science board decided to put on the OCF site. There are thousands of studies, some better than others. For those of you that want to go searching here is your starting point

Early information

http://www.oralcancerfoundation.org/facts/hpv_reports.htm

information since 2000

http://www.oralcancerfoundation.org/hpv/hpv-scientific-articles.html

Vaccine

http://www.oralcancerfoundation.org/hpv/hpv-vaccine-related-articles.html

other stuff

http://www.oralcancerfoundation.org/hpv/

All this is being updated this month. But much of this multiple thread discussion misses the point that just about every adult in the US is going to be exposed. It is impossible to know when, or by whom, since you do not know you have the virus, and you do not know that you have cleared it. (How could someone intentionally harm another through transmission, when you can't even know that you have it, and the persons that you are having sex with will likely be part of the naturally protected 99% of the population) Only about .9% of those exposed to an oncogenic HPV orally develop a cancer from it. Do the math. These are approximations;

US population, 300 million, likely 50 million too young to have sex and 50 million too old to be having sex. That leaves about 200 million people, most of whom will get the HPV virus. Out of 200 million people about 12-15k got an oral cancer from it last year. Someone do the math and tell us how many zeros come after the decimal point in that percentage to calculate what your odds are of getting this. The odds are very, very small. We are a very small, unlucky club. The good news is that we do better than people whose etiology is tobacco or an unknown cause (7%). We also have very few recurrences of an HPV etiology OSCCC. 30,000 or more people will die on US freeways in 2014. 8 thousand will die from oral cancer and not even half of those from an HPV etiology. I won't even comment on the legal discussion that has gone on. There is a lot we do not know, actually the numbers we are using today are not always accurate since reporting over the last decade has been hap hazard, even by the best hospitals who didn't even test for it in OSCC patients. Combine that with what we know, we don't know, which is vast, and much of this discussion does not have a finite answer to the questions asked in it.

To answer Tonys question, it appears that treatments do not eliminate the virus, and that post treatment we can still be HPV+. This was published by Gillison years ago. This really isn't a surprise given that the virus if it is dormant/active/dormant/active as some suspect, could be residing in an anatomical site not in the field of treatment. Herpes Simplex Virus which you get for life, lives on the ganglion of your nerves when it is dormant, and can be widely distributed. That is just one real life example, and in HPV we don't even have actual proof that it is dormant, though many good science people believe so in spite of the lack of evidence of it. (We have never found it in a dormant state anywhere.) It does account for why people that have had monogamous relationships for decades suddenly get a HPV+ cancer, but the opposite problem also exists. There have been 20 year olds with and HPV+ OSCC. Yes, there is birth canal transfer as a possibility, and that would give you a couple decades again. But none of this has any evidence pro or con.

Is it possible to blood test for p16?

Thankyou Brian. That sensible post was much needed.
Tammy

No

As far as my comment made in the previous HPV postings, it was to add to the laymen's discussion in the patient/survivor forum post about one blogger's comment, n74tg, aboutthe possible law and HPV, and I did post what New York State's Law is as far as STD's as a "Ripley's believe it or not" that there is a law, and HPV may be interpeted as such, to make a lively discusssion most of which some others go dead after a few threads. Do I blieve it can or will be inforced? No. Is it possible? Maybe, and there are plenty other laws on the books one would be surpsised to learn that may be outdated, but still in the penal law.

Anyway, and just to counter the comment how one would know they are infeted with HPV-16? I'm not talking about that, and don't think the others are either nor questions were about. We are talking about sonmeone who is told they are HPV-16 positive, have cancer, and has not been treated or cancer eradicated by clear PET scan, and thinkimg about dating or a one night stand. I think there is a difference in thought for those here that are married or in a manogpomous long term relationship as opposed to those of us who are single, and not in monmogomous relationship, and don't intend to be. There may be an age differecencr too, although I'm not over the hill yet, I'm 52, single and free, married and divorvced twice, but still looking for the third charm lol. A guy like n74tg, Tony, is probqably like John Travolta on the dance floor, and quite popular, so I understand his dating concerns. The subject also touches many other concerns like education, sexuality, moral, ethical, social and health issues, and for some, a legal interest. I don't think this will be resolved anytime soon since there is more unknown about HPV Head and neck cancer than there is known, unlike cervical cancer, and if predictions are correct, this disease, OPHNSCC, will surpass cervical cancer by 2020, and many more dfiscusssions, questions will follow.

Paul, you bring up a valid discussion point. Is HPV and HSV, for that matter, a "declarable" virus from a legal perspective. Only time will tell but definitely a worthwhile discussion in today's world. P

Help me out...

Is that o.O or O.o

lol

Have a great day Paul!

Wow, I'm honored, I only wish I was as popular as John Travolta on the dance floor.

[quote]I'm 52, single and free, married and divorvced twice, but still looking for the third charm [/quote]

In actuality, add 10 years to the age and this describes me perfectly (except that I can spell divorced).

Tony

Is HPV -16 only aquired through Oral Sex or can it be aquired by French Kissing?

I haven't seen any study or even a paper on that but I have been told by Moffitt's head HPV researcher, a Phd, that it's possible to pass the virus that way.

Ed it's O.o lol.

Tony, I know you were joking about the spell, but just a little waiver here for everyone to know about my spelling lol. I'm half blind, it's totally black in my left eye, which vision I lost from chemo, and eye surgery did not work. So I'm permanently blind, and almost lost my right vision, which took a year for my Opthomolgist surgeon to save, still is, and have all these tests done, even a sonogram, on my good eye every three months, but still have problems with both eyes. My right eye I have to physically open after I sleep each morning with my fingers, burns like hell, pain, and use dry eye drops, and sometimes steroids to help, and then sometimes it's too watery, which can be reflective from my left eye, which gets irritated, has pain, is half closed, color is dark. As a result, my depth perception is off, I misjudge stairs, curbs, cutting (yes I cut a piece of my finger off lol), pouring liquids in a glass, and I have problems typing on the iPad key pad, computer too, which fonts went to micro with a virus, and misjude the letters, and the fonts are blurred, especially in the mornings, probably after ambiem, gabaoentin, and when my glucose is high, and hemoglobin is low I see white patches which blurs my vision, and computer light bothers me. Here is another thing being a movie hobbyist, I found out I can't see in 3D. I was in all these stores looking at 3D Tv displays, and thought they were junk lol. I though about it, and ascertained I can only see in 2D. You need both eyes to see 3D. Also, I don't paste and copy. I type as if I'm speaking. Maybe edit some spell afterwards. It's all good, I'm happy, and it could be worse, but always worry about losing my vision totally.

All the best, and back to HPV lol.

I have one question that keeps bugging me and I still cant find all the answers(on top of that I am very scared for my life now)and suffer from anxiety issues because of this
my pap smear was normal but what about my mouth or tonsil( I engaged in oral sex)If it didnt cause any cell change in my cervix how likely is it to cause cell changes in my Throat/Tonsils?I am also suffering from Chronic Tonsillitis.

Paul, forgive me for making light of it, my friend. After the first time we were joking about it, I always chuckle now. Nothing personal.

I have never had depth perception or at least since about 1964. It caused a few problems getting a license to drive. I only clipped one car in my life changing lanes so I guess I learned well.

Since I am in the iPad world these days I recognize even standard misspellings. No worries.

O.o

No offense. Just my typing excuse, and loss of patience correcting.

a1234,

Science wishes it knew why the virus causes cancer some of the time and not the majority of times so unfortunately your logical questions can not be answered.

NPR's "Diane Rehm Show" just spent an hour discussing the HPV vaccine. More info here; podcast info here.