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#55539 09-28-2004 03:05 PM
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ssax Offline OP
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Hi,
Not too long ago, I developed thrush, post-radiation. The first doctor I saw prescribed a 200 mg. dose of diflucan and then a second dose of 100 mg. to be taken 2 days later, followed by another 100 mg. dose.
While getting the prescription filled, the pharmacist looked up the recommended dosage and said that the minimum treatment of diflucan is 14 days. Another doctor said that usually 5-7 days of treatment is enough to knock out thrush and if it doesn't, another drug is required as continued intake of diflucan won't make much difference.
For those of you who have had thrush and were treated for it with diflucan, what was the course of your treatment?
Thanks, Sheldon


Dx 1/29/04, SCC, T2N0M0
Tx 2/12/04 Surgery, 4/15/04 66 Gy. radiation (36 sessions)
Dx 3/15/2016, SCC, pT1NX
Tx 3/29/16 Surgery
#55540 09-28-2004 10:05 PM
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Hi Sheldon,
I made medical history at UCSF CCC for being on Diflucan the longest of any patient they knew of! I was up to 400 mg a day at one point and 200mg/day was the maintenance dose (actually the manufacturer recommends 50 mg/day for maintenance). I was on it for months - so long that it temporarily supressed my white cell count. Although they thought that it was a huge amount I found instances of AIDS patients taking up to 800mg/day.


Gary Allsebrook
***********************************
Dx 11/22/02, SCC, 6 x 3 cm Polypoid tumor, rt tonsil, Stage III/IVA, T3N0M0 G1/2
Tx 1/28/03 - 3/19/03, Cisplatin ct x2, IMRT, bilateral, with boost, x35(69.96Gy)
________________________________________________________
"You are a mist that appears for a little while and then vanishes" (James 4:14 NIV)
#55541 09-29-2004 02:16 AM
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Sheldon,
I too was on Diflucan for 7 months (on and off) after my treatment. The thrush kept coming back. Doesnt any more though and I am 8 months post treatment, 1 year post diagnosis.

Take it easy.
Robert


SCC 1.6cm Right Tonsil 10/3/03, 1 Node 3cm, T1N2AM0, Tonsil Removed, Selective Neck Disection, 4 Wks Induction Chemo (Taxol,Cisplatin), 8 Weeks Chemo/Radiation (5FU,Hydroxyurea,Iressa), IMRT x 40, Treatment Complete 2/13/04.
41 Years Old At Diagnosis
#55542 09-29-2004 03:16 AM
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Sheldon,
I was on Diflucan for several months while on treatment and just after. Also if I take any antibiotic I still get thrush and I'm 3 years out!


JOAN
#55543 09-29-2004 04:38 AM
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Sheldon, You might ask to try Nystatin swish (perhaps you have already) It is more of a contact anti-thrush rather than a systemic treatment like Diflucan. Nystatin always works for me. (yes I still need it maybe once a month)
Larger doses of Diflucan can be a bit hard on the liver whereas the Nystatin swish seems to have few side effects (they give it to babies)

Just a thought.


Mark, 21 Year survivor, SCC right tonsil, 3 nodes positive, one with extra-capsular spread. I never asked what stage (would have scared me anyway) Right side tonsillectomy, radical neck dissection right side, maximum radiation to both sides, no chemo, no PEG, age 40 when diagnosed.
#55544 09-29-2004 10:27 AM
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ssax Offline OP
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Thanks, Mark.
I tried the Nystatin swish but it burned my tongue so I asked for a systemmic alternative. It also felt like it was so loaded with sugar that it was dissolving my teeth. - Sheldon


Dx 1/29/04, SCC, T2N0M0
Tx 2/12/04 Surgery, 4/15/04 66 Gy. radiation (36 sessions)
Dx 3/15/2016, SCC, pT1NX
Tx 3/29/16 Surgery
#55545 09-29-2004 01:48 PM
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Sheldon,

I had a bad battle with thrush for many months and I only took 40 mg twice daily (liquid) but usually for 14 days. I had just finished hep c treatment when the cancer was found and had liver issues so I tried to avoid the Diflucan since I could feel it in my liver. (I guess it made my liver quiver.)

I tried a biopathic product called Threelac that is acidophillus and a couple other digestive enzymes. It seemed to do the trick without the liver discomfort. I took a double dose and it was about $65/month. It is not on Quackwatch, by the way.

Ed


SCC Stage IV, BOT, T2N2bM0
Cisplatin/5FU x 3, 40 days radiation
Diagnosis 07/21/03 tx completed 10/08/03
Post Radiation Lower Motor Neuron Syndrome 3/08.
Cervical Spinal Stenosis 01/11
Cervical Myelitis 09/12
Thoracic Paraplegia 10/12
Dysautonomia 11/12
Hospice care 09/12-01/13.
COPD 01/14
Intermittent CHF 6/15
Feeding tube NPO 03/16
VFI 12/2016
ORN 12/2017
Cardiac Event 06/2018
Bilateral VFI 01/2021
Thoracotomy Bilobectomy 01/2022
Bilateral VFI 05/2022
Total Laryngectomy 01/2023
#55546 09-29-2004 03:57 PM
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Hi Sheldon,
I'm on a permanent dose of Nystatin. Came back from Vegas with a mild case because forgot to take it. It does burn somewhat until it starts to clear up and then ok.

However, during and after I had radiation back in the dark ages, I had thrush so badly I was on both nystatin and diflucan for months. They finally had to put me on a steroid, dexamethasone, for several weeks before it cleared up. Of course, no one bothered to tell me I was not supposed to be eating or drinking anything with sugar or that could turn into sugar, ie. nothing white. There is a whole section on this someplace on this site. Read up on it. Take the Nystatin and watch the sugar and if that doesn't clear it, see the dr.

Hope your flight home wasn't too long. Great to meet you.

uyyyyyyyyy66666666 This post is from my cat, Skippy. Just danced on the keyboard.

Take care,
Eileen


----------------------
Aug 1997 unknown primary, Stage III
mets to 1 lymph node in neck; rt ND, 36 XRT rad
Aug 2001 tiny tumor on larynx, Stage I total laryngectomy; left ND
June 5, 2010 dx early stage breast cancer
June 9, 2011 SCC 1.5 cm hypo pharynx, 70% P-16 positive, no mets, Stage I
#55547 09-30-2004 03:12 PM
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Sheldon- That Three Lac stuff is wonderful. Ed had thrush so bad at one point he laid there (over Labour Day weekend/mid-treatment) crying from the pain (maybe his 3rd degree radiation burns had something to do with it). Once we found the Three Lac and the Domeboro Soak he never had any more radiation burn OR thrush (though we thought we were close a few times). It may not be right for you but dang, it was great at our house.

Have a great evening!


Caregiver to Uptown/Ed, SCC Stage IV, Base of tongue - Completed Chemo (Cisplatnin/5FU) and 45 days' simultaneous Radiation 10/08/03
#55548 09-30-2004 06:56 PM
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In my experience the burning means thrush, when the burning stops, no more thrush. You are right the nystatin is sweet however I understand it is prepared with an artificial sweetener. I haven't lost my teeth yet laugh and one of the ways I use Nystatin is by swishing just before bed. That way the stuff is working all night. Another natural treatment that seems to help is to eat lots of live culture yoghert.


Mark, 21 Year survivor, SCC right tonsil, 3 nodes positive, one with extra-capsular spread. I never asked what stage (would have scared me anyway) Right side tonsillectomy, radical neck dissection right side, maximum radiation to both sides, no chemo, no PEG, age 40 when diagnosed.
#55549 10-02-2004 06:07 PM
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Strange enough, I had a little bout of thrush when we got home and I could feel it coming on after I drank some cream soda at the Forum. I think it was the first soda I had all year and now I remember why I stopped.

Ed


SCC Stage IV, BOT, T2N2bM0
Cisplatin/5FU x 3, 40 days radiation
Diagnosis 07/21/03 tx completed 10/08/03
Post Radiation Lower Motor Neuron Syndrome 3/08.
Cervical Spinal Stenosis 01/11
Cervical Myelitis 09/12
Thoracic Paraplegia 10/12
Dysautonomia 11/12
Hospice care 09/12-01/13.
COPD 01/14
Intermittent CHF 6/15
Feeding tube NPO 03/16
VFI 12/2016
ORN 12/2017
Cardiac Event 06/2018
Bilateral VFI 01/2021
Thoracotomy Bilobectomy 01/2022
Bilateral VFI 05/2022
Total Laryngectomy 01/2023
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