My husband used Zofran the entire 7 weeks of radiation and chemo (plus amifostine) and it worked as well at the end as at the beginning. When it didn't seem to do the job was two days after chemo treatment (which was weekly, Wednesday afternoon) -- when the Anzemet he was given that afternoon had worn off and he had to deal with the amifostine Friday morning. Then the Zofran (taken 90 minutes before the ethyol/amifostine) was not enough, he would get very queasy and nauseated. Adding Compazine did zip and Anzemet wasn't much better so he eventually dropped amifostine on Fridays. It didn't seem to reduce effectiveness much.

It appears that people can respond differently to these medications, some report being helped a lot by compazine, some not at all and so on.

Garry is quite right about the other factors triggering nausea. Barry had to stop taking oxycodone as it gave him gastric reflux and some nausea --- he went to the Duragesic patch (25 mg) and that caused him no serious issues.

Zofran is expensive, but Barry said it was worth every penny. Luckily he had some state prescription coverage but we just did our tax forms and were appalled at how much he spent last year on medications. But that's a different topic...

Gail