| | Joined: Apr 2013 Posts: 319 Platinum Member (300+ posts) |  Platinum Member (300+ posts)
Joined: Apr 2013 Posts: 319 | I had Taxetere with Carboplatin for 2 cycles (1/wk x3, +1 wk off) after I had mentioned to my MO that I had experienced some additional hearing loss under Taxol/Carbo.
He said he did so (change the Taxol for Taetere) because Taxetere was formulated to reduce the neuropathy that Taxol causes.
That suggests that Taxol mght be more effective for you, being stronger.
I also knocked out my latest recurrence with Xeloda, a pill form of 5FU. It took 5 cycles (14 days @ 3000 mg/day + 7 days off = a cycle) Just got the word that I'm clean, three weeks ago.
My intro: http://oralcancersupport.org/forums/ubbt...3644#Post16364409/09 - Dx OC Stg IV 10/09 - Chemo/3 Cisplatin, 40 rad 11/09 - PET CLEAN 07/11 - Dx Stage IV C. (Liver) 06/12 - PET CLEAN 09/12 - PET Dist Met (Liver) 04/13 - PET CLEAN 06/13 - PET Dist Met (Liver + 1 lymph node) 10/13 - PET - Xeloda ineffective 11/13 - Liver packed w/ SIRI-Spheres 02/14 - PET - Siri-Spheres effective, 4cm tumor in lymph-node 03/15 - Begin 15 Rads 03/24 - Final Rad! Woot! 7/27/14 Bart passed away. RIP!
| | | | | Joined: Jun 2011 Posts: 188 Senior Member (100+ posts) | | Senior Member (100+ posts)
Joined: Jun 2011 Posts: 188 | Hi Eshwar, sorry I'm late to this...Pop was readied 2x for that trial but has yet to participate as complications popped up. I hope your world is calm.
Zenda, can you talk more about re Alimta? What stage in treatment did you participate?
Caco
CG to Dad. Biopsy 5/11 non-op, SCC stage IV poorly dif at base of tongue with nodes, quit smoking in '85, ChemoRad began 8/2/11 ended 9/22/11 with NED. Distant mets 11/11, clinical trials. War raging on!
| | | | | Joined: Feb 2005 Posts: 118 Likes: 1 Senior Member (100+ posts) | | Senior Member (100+ posts)
Joined: Feb 2005 Posts: 118 Likes: 1 | Caco,
I participated in a Phase 1 clinical trial of Alimta with TRC 102 from Tracon Pharmaceuticals NCT 0062159 from 3/2/09 until 4/10/10. A RUL nodule disappeared and a right hilar lymph node decreased in size from 2.4 cm to 1.4 cm and then maintained until my 3/10 PET which showed that the lymph node had increased to 2.2 cm. At that time I dropped from the trial. The phase 1 portion of the trial had actually stopped several months earlier, but, because I was continuing to benefit from the meds, Tracon continued to provide them at no charge with the trial protocol continuing. I had such minimal side effects that I was able to travel, camp, do volunteer activities throughout the year. I believe there was a presentation made at ASCO detailing the results of this phase 1, and I recall that I was one of the few who benefited for this period of time with this drug combo. I have not followed the further testing, if, in fact, there were additional phases.
Where is your dad in his treatment plan now?
Be well. Zenda
12/04 SCC Tonsil, Stage IV T3N2BM0. Mod RND, resect right oropharynx, free-flap, resect right tongue base. Erbitux,Docetaxel,RT X 33. 6/08 Mets lung, hilar lymph node:Carboplatin, Docetaxel. 2010 2nd clinical trial:lung clear, node stable. ORN,trismus,dysphagia. 8-10/2012 cryoablation,brachytherapy,cyberknife to lymph node. 12/12 NED. 6/13 Mets RLL lung: 8/13 cyberknife. 11/13 NED.
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