I had daily Amifostine for each of my 39 IMRT treatments, even though I did not have any bulky nodes near radiation field. (I had bilateral neck dissection prior to IMRT). I had transient nausea (a few minutes) for about the last 4 weeks of treatment, but nothing that could be characterized as signficant.

I had both submadibular glands removed during the neck dissection, so they wanted to preserve as much function as possible. There are lots of theories, but the amifostine/cancer connection is not prevailing thought.

I have decent salivary function today, some days better than others, but have no way of knowing what it would have been without the Amifostine.