After two Cisplatin treatments, I experienced significant hearing changes, which prompted the chemo doc to switch me to other meds. My heariing returned to normal. This doc told me that he had one patient long ago who suffered profound hearing loss after Cisplatin, and that some people are more at risk of this than others. The other meds caused me to lose my hair, but it grew back and I can hear a pin drop, so I think that was a pretty decent trade. Bottom line - there are options to Cisplatin if one experiences hearing changes during treatment.