I am very sorry to hear this latest development. As you are no doubt aware, liver cancer is a serious diagnosis, and getting into a clinical trial was the smartest thing that your doctor could do for you since success with the conventional treatments is not high enough to instill comfort and confidence in cure. Remember that in order for a new treatment or drug to qualify to be used in a clinical trial it has to be proven to be AT LEAST as good as established treatments. So you are not taking any risks by getting into a program. Regarding the metastasis of oral and other cancers; there are two significant issues, 1. What is practical and reasonable to do within the scope of expected risks (mets to the aero digestive tract associated with oral