Rosie, I have had several PICC lines, the first one ran well , the second clogged, I went to my local hospital which is only ten minutes away and the IV nurse there took care of it. My hospital called and made the arrangements for that. The Iv gals say the new prepared syringes only have 3 cc of Heprin and the saline the same.They think 5cc works better. I had to measure the Heprin myself from a bottle and did 5cc for the first PICC line and all was well even though you had to watch for air bubbles more and it was more of a pain to do. I ran antibiotics thru ever four hours. I stayed up late at nite and my husband did the morning one. I would sleep thru that one. If you are using 3 and you still have trouble ask about 5, I used for a week ,just used the prepared syringe and stopped second when I had flushed with 5. They have to order you more supplies, but if it helps??? Glad she got home!